Breast cancer in octogenarian. Are we doing our best? A population-registry based study
| Autor: | Raquel Queralt-Martín, David Martínez-Ramos, Javier Escrig-Sos, Laura Simón-Monterde, Consuelo Suelves-Piqueres, Pedro Menor-Duran |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
medicine.medical_specialty Population Breast Neoplasms Kaplan-Meier Estimate 030230 surgery 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Humans Medicine Registries Stage (cooking) Propensity Score education Survival analysis Aged Neoplasm Staging Proportional Hazards Models Retrospective Studies Aged 80 and over education.field_of_study business.industry Proportional hazards model Age Factors Cancer General Medicine Middle Aged medicine.disease Cancer registry Survival Rate Chemotherapy Adjuvant Spain 030220 oncology & carcinogenesis Propensity score matching Female Surgery business |
| Zdroj: | The Breast. 38:81-85 |
| ISSN: | 0960-9776 |
| Popis: | BACKGROUND The number of old people with breast cancer is estimated to increase during the next years in developed countries. However, management of breast cancer in octogenarians is not well established. The main objective was to evaluate if patients older than 80 years with breast cancer are receiving the most convenient treatment by using a population registry cancer analysis. PATIENTS AND METHODS A retrospective analysis of a population cancer registry was designed. Data were retrieved from the Castellon Cancer Registry (Valencian Community, Spain). Patient records were analyzed from January 1, 1995 to December 31, 2013. Two groups were defined: group A, = 80 years. Survival analyses were sequentially performed into three phases. First, a non-adjusted Kaplan Meier analysis was conducted. For the second survival analyses, Cox's proportional hazards model of Overall survival was used adjusting for condensed-TNM stage and adjuvant treatments. Finally, the third specific adjustment was carried out adding information of life expectancy by age for Spanish women, corresponding to year 2008 with condensed-TNM stage and Propensity Score variable, as an approximation to relative or disease-specific survival. RESULTS The total number of included patients was 1304. Women ≥80 years presented a more extended disease, larger tumors and less in situ carcinomas. A lower proportion of women ≥80 years received adjuvant therapies. In the absence of any adjustment of results, the overall survival in women ≥80 years was poorer than in younger patients (median of 14.1 years for |
| Databáze: | OpenAIRE |
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