Evidence for default mode network dysfunction in borderline personality disorder
| Autor: | Edith Pomarol-Clotet, Cristina Brunel, Teresa Maristany, Pilar Salgado-Pineda, Ana Martín-Blanco, Juan C. Pascual, Antoni Rodríguez-Fornells, Peter J. McKenna, Salvatore Aguilar-Ortiz, Joaquim Soler, Josep Marco-Pallarés, Raymond Salvador, Àngel Soto, Daniel Vega, Salvador Sarró, Joan Ribas |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Precuneus functional imaging Audiology behavioral disciplines and activities Young Adult 03 medical and health sciences default mode network 0302 clinical medicine Borderline Personality Disorder Parietal Lobe Cortex (anatomy) mental disorders History of depression medicine Humans Borderline personality disorder Applied Psychology Default mode network Brain Mapping neuroimaging Working memory business.industry Default Mode Network Cognition medicine.disease Magnetic Resonance Imaging 030227 psychiatry Functional imaging Psychiatry and Mental health Memory Short-Term medicine.anatomical_structure Spain Case-Control Studies Female business 030217 neurology & neurosurgery |
| Zdroj: | PSYCHOLOGICAL MEDICINE r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu Fundació Sant Joan de Déu r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu |
| ISSN: | 0033-2917 |
| Popis: | BackgroundAlthough executive and other cognitive deficits have been found in patients with borderline personality disorder (BPD), whether these have brain functional correlates has been little studied. This study aimed to examine patterns of task-related activation and de-activation during the performance of a working memory task in patients with the disorder.MethodsSixty-seven DSM-IV BPD patients and 67 healthy controls underwent fMRI during the performance of then-back task. Linear models were used to obtain maps of within-group activations and areas of differential activation between the groups.ResultsOn corrected whole-brain analysis, there were no activation differences between the BPD patients and the healthy controls during the main 2-backv.baseline contrast, but reduced activation was seen in the precentral cortex bilaterally and the left inferior parietal cortex in the 2-backv.1-back contrast. The patients showed failure of de-activation affecting the medial frontal cortex and the precuneus, plus in other areas. The changes did not appear to be attributable to previous history of depression, which was present in nearly half the sample.ConclusionsIn this study, there was some, though limited, evidence for lateral frontal hypoactivation in BPD during the performance of an executive task. BPD also appears to be associated with failure of de-activation in key regions of the default mode network. |
| Databáze: | OpenAIRE |
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