Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity: a multi-center study
| Autor: | Clemens Mellink, Šárka Pospíšilová, Paolo Ghia, Constantine S. Tam, Mar Bellido, Marie Jarošová, Richard Rosenquist, Eva van den Berg, Jacqueline Schoumans, Claudia Haferlach, Lotta Hansson, Zadie Davis, Blanca Espinet, Anna Puiggros, David Oscier, Eric Eldering, Marian Stevens-Kroef, Jonathan C. Strefford, Panagiotis Baliakas, Karla Plevová, Ana E. Rodríguez-Vicente, Alexander C. Leeksma, Kostas Stamatopoulos, Rebeqa Gunnarsson, Pino J Poddighe, Anne Marie van der Kevie-Kersemaekers, Arnon P. Kater, Meaghan Wall, Florence Nguyen-Khac, Theodoros Moysiadis, Anders Österborg, Anh Nhi Tran, Larry Mansouri, Ilaria Scarpelli, Hidde Posthuma, Gisela Barbany, Loic Ysebaert, Helen Parker |
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| Přispěvatelé: | Gilead Sciences, Kay Kendall Leukaemia Fund, Cancer Research UK, Wessex Medical Research, Swedish Research Council, Knut and Alice Wallenberg Foundation, Karolinska Institute, Graduate School, AII - Cancer immunology, CCA - Cancer biology and immunology, Human Genetics, Experimental Immunology, Clinical Haematology, Amsterdam Reproduction & Development (AR&D), Leeksma, A. C., Baliakas, P., Moysiadis, T., Puiggros, A., Plevova, K., van der Kevie-Kersemaekers, A. -M., Posthuma, H., Rodriguez-Vicente, A. E., Tran, A. N., Barbany, G., Mansouri, L., Gunnarsson, R., Parker, H., van den Berg, E., Bellido, M., Davis, Z., Wall, M., Scarpelli, I., Osterborg, A., Hansson, L., Jarosova, M., Ghia, P., Poddighe, P., Espinet, B., Pospisilova, S., Tam, C., Ysebaert, L., Nguyen-Khac, F., Oscier, D., Haferlach, C., Schoumans, J., Stevens-Kroef, M., Eldering, E., Stamatopoulos, K., Rosenquist, R., Strefford, J. C., Mellink, C., Kater, A. P., CCA - Cancer Treatment and quality of life, Human genetics |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty GENES Genomic complexity Chronic lymphocytic leukemia Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2] FEATURES ABERRATIONS Article 03 medical and health sciences 0302 clinical medicine Internal medicine hemic and lymphatic diseases medicine Humans Chronic Lymphocytic Leukemia Hematologi Cytogenetics and Molecular Genetics Lymphoproliferative Disorders Chromosome Aberrations Hematology business.industry Hazard ratio Cytogenetics Cancer KARYOTYPE Genomics CHEMOTHERAPY medicine.disease Leukemia Lymphocytic Chronic B-Cell CYTOGENETICS 3. Good health Leukemia 030104 developmental biology 030220 oncology & carcinogenesis Multiple comparisons problem SURVIVAL Medical genetics business CLL HYBRIDIZATION RESISTANCE |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname Haematologica, 105(5). Ferrata Storti Foundation Haematologica, 106, 87-97 Haematologica, vol. 106, no. 1, pp. 87-97 Haematologica, 106(1), 87-97. FERRATA STORTI FOUNDATION Haematologica, 106, 1, pp. 87-97 Leeksma, A C, Baliakas, P, Moysiadis, T, Puiggros, A, Plevova, K, van der Kevie-Kersemaekers, A M, Posthuma, H, Rodriguez-Vicente, A E, Tran, A N, Barbany, G, Mansouri, L, Gunnarsson, R, Parker, H, van den Berg, E, Bellido, M, Davis, Z, Wall, M, Scarpelli, I, Österborg, A, Hansson, L, Jarosova, M, Ghia, P, Poddighe, P, Espinet, B, Pospisilova, S, Tam, C, Ysebaert, L, Nguyen-Khac, F, Oscier, D, Haferlach, C, Schoumans, J, Stevens-Kroef, M, Eldering, E, Stamatopoulos, K, Rosenquist, R, Strefford, J C, Mellink, C, Kater, A P & ERIC, the European Research Initiative on CLL 2020, ' Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity : A multi-center study ', Haematologica, vol. 105, no. 5 . https://doi.org/10.3324/HAEMATOL.2019.239947 Haematologica |
| ISSN: | 6526-9705 0390-6078 |
| DOI: | 10.3324/HAEMATOL.2019.239947 |
| Popis: | Complex karyotype (CK) identified by chromosome-banding analysis (CBA) has shown prognostic value in chronic lymphocytic leukemia (CLL). Genomic arrays offer high-resolution genome-wide detection of copy-number alterations (CNAs) and could therefore be well equipped to detect the presence of a CK. Current knowledge on genomic arrays in CLL is based on outcomes of single center studies, in which different cutoffs for CNA calling were used. To further determine the clinical utility of genomic arrays for CNA assessment in CLL diagnostics, we retrospectively analyzed 2293 arrays from 13 diagnostic laboratories according to established standards. CNAs were found outside regions captured by CLL FISH probes in 34% of patients, and several of them including gains of 8q, deletions of 9p and 18p (p This study was partly funded by an unrestricted contribution from Janssen Pharmaceuticals and from GILEAD Sciences SA. A.C.L. is supported by the Peters van der Laan foundation. J.C.S. was funded by Bloodwise (11052, 12036), the Kay Kendall Leukaemia Fund (873), Cancer Research UK (C34999/A18087, ECMC C24563/A15581), Wessex Medical Research and the Bournemouth Leukaemia Fund. K.P., M.J., and S.P. are supported by the project MHCR DRO no. 65269705, the research infrastructures NCMG LM2015091, and EATRIS-CZ LM2015064, and the project CEITEC2020 LQ1601, funded by MEYS CR. R.R. is supported by Swedish Cancer Society, the Swedish Research Council, the Knut and Alice Wallenberg Foundation, Karolinska Institutet, Karolinska University Hospital, and Radiumhemmets Forskningsfonder, Stockholm. |
| Databáze: | OpenAIRE |
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