Cellular Senescence as a Target in Cancer Control
| Autor: | Amancio Carnero, Mar Vergel, Purificacion Estevez, Juan J. Marin |
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| Přispěvatelé: | Instituto de Biomedicina de Sevilla (IBIS), Universidad de Sevilla. Departamento de Medicina Preventiva y Salud Pública |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Senescence
Somatics cells DNA damage Somatic cell Population Review Article Biology lcsh:Geriatrics Cellular senescence Multinucleate Cytotoxic T cell education education.field_of_study Tumor Mechanism (biology) Oncogenic stress Anticancer therapy Multinucleated lcsh:RC952-954.6 Telomerase inhibitors Apoptosis Immunology Cancer research Geriatrics and Gerontology Cancer control |
| Zdroj: | Journal of Aging Research idUS. Depósito de Investigación de la Universidad de Sevilla instname Journal of Aging Research, Vol 2011 (2011) Digital.CSIC. Repositorio Institucional del CSIC |
| ISSN: | 2090-2212 2090-2204 |
| Popis: | 12 páginas, 1 figura, 1 tabla. Somatic cells show a spontaneous decline in growth rate in continuous culture. This is not related to elapsed time but to an increasing number of population doublings, eventually terminating in a quiescent but viable state termed replicative senescence. These cells are commonly multinucleated and do not respond to mitogens or apoptotic stimuli. Cells displaying characteristics of senescent cells can also be observed in response to other stimuli, such as oncogenic stress, DNA damage, or cytotoxic drugs and have been reported to be found in vivo. Most tumors show unlimited replicative potential, leading to the hypothesis that cellular senescence is a natural antitumor program. Recent findings suggest that cellular senescence is a natural mechanism to prevent undesired oncogenic stress in somatic cells that has been lost in malignant tumors. Given that the ultimate goal of cancer research is to find the definitive cure for as many tumor types as possible, exploration of cellular senescence to drive towards antitumor therapies may decisively influence the outcome of new drugs. In the present paper, we will review the potential of cellular senescence to be used as target for anticancer therapy. This work was supported by Grants from the Spanish Ministry of Science and Innovation (SAF2009-08605) and Consejeria de Salud, Junta de Andalucia (PI-0142). A. Carnero’s Lab is also funded by a fellowship from Fundacion Oncologica FERO supported by Fundacio Josep Botet |
| Databáze: | OpenAIRE |
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