Glutathione S-transferase enzyme activity and protein expression in patients with recurrent tonsillitis and idiopathic tonsillar hypertrophy
| Autor: | Can Yilmaz, Sedat Aydin, Serpil Oguztuzun, Murat Kiliç, Mehmet Gökhan Demir, Onur Dirican |
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| Přispěvatelé: | Kırıkkale Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
gsta1 medicine.medical_specialty Adolescent Palatine Tonsil Tonsillitis recurrent tonsillitis lcsh:Medicine 030204 cardiovascular system & hematology Gastroenterology Isozyme General Biochemistry Genetics and Molecular Biology Palatine tonsil Muscle hypertrophy Pathogenesis 03 medical and health sciences GSTP1 0302 clinical medicine stomatognathic system Internal medicine otorhinolaryngologic diseases Humans Medicine idiopathic tonsillar hypertrophy Child glutathione s-transferase Glutathione Transferase biology business.industry lcsh:R Proteins Hypertrophy respiratory system medicine.disease gstp1 medicine.anatomical_structure Glutathione S-transferase Child Preschool 030220 oncology & carcinogenesis Tonsil biology.protein Female business |
| Zdroj: | Biomedical Papers, Vol 163, Iss 4, Pp 349-354 (2019) |
| Popis: | demir, mehmet/0000-0002-0609-6782; Kilic, Murat/0000-0002-1377-2021 WOS: 000506054400010 PubMed: 30765895 Objectives. The palatine tonsil is a significant part of the secondary immune system. Tonsillitis and idiopathic tonsillar hypertrophy (ITH) are the most common pathologies of this component. Although there are studies on their pathogenesis, there is insufficient study of the role of antioxidant agents. Glutathione S-transferase (GST) isozymes contribute to the antioxidation reactions in the tissue via the glutathione pathway. The purpose in this study was to reveal the levels of the GST enzyme activity and protein expression of GSTP1 and GSTA1 isozymes in patients with tonsillitis and tonsil hypertrophy, and to investigate their role in the pathogenesis of these diseases. Materials and Methods. Sixteen patients with recurrent tonsillitis and 5 patients with ITH and were included in the study. Cytosolic extracts were prepared from post-tonsillectomy tissues of both patient groups and GST enzyme activities were measured. Results. The expression of GSTP1 was found to be significantly higher than GSTA1 in tissue samples of patients with ITH and recurrent tonsillitis (P |
| Databáze: | OpenAIRE |
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