NFATc1 is Suppressed in Tumor Microenvironment of Hodgkin Lymphoma
| Autor: | Riana Sari Puspita Rasyid, Krisna Murti, Nyiayu Fauziah Kurniawati, Ika Kartika, Neti Neti, Zen Hafy |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male PD-L1 Antigens Differentiation Myelomonocytic NFATc1 Receptors Cell Surface B7-H1 Antigen Antigens CD Biomarkers Tumor Tumor Microenvironment Humans Distribution (pharmacology) Tumor microenvironment NFATC Transcription Factors integumentary system biology General Medicine Middle Aged Hodgkin Disease Cytoplasm Cancer research biology.protein Hodgkin lymphoma Immunohistochemistry Female CD163 Antibody Research Article |
| Zdroj: | Asian Pacific Journal of Cancer Prevention : APJCP |
| ISSN: | 2476-762X |
| DOI: | 10.31557/apjcp.2021.22.6.1943 |
| Popis: | Objective The aims of this research are to evaluate the expression and distribution of NFATc1 in tumor microenvironment of Hodgkin lymphoma. Methods Twenty-eight cases of Hodgkin lymphoma were selected. Clinicopathological data of age, gender, location and subtypes were obtained. Immunohistochemistry was performed to the all cases by using anti-CD163, anti-NFATc1 and anti-PD-L1 antibodies. All protein expression was calculated by using Image J software. Results Nuclear expression of NFATc1 was not observed in Hodgkin cells neither in TAM nor in small lymphocytes surrounding Hodgkin cells in all the samples, this meant that NFATc1 showed negative nuclear expression in almost all these cells. Cytoplasmic expression of NFATc1 was observed in small lymphocytes surrounding tumor cells. While there were only few small lymphocytes which were located far from tumor cells showed nuclear expression of NFATc1. Meanwhile, 57.14% samples showed high density of TAMs CD163+, and 50% tumor cells as well as 50% TAMs exhibited positive PD-L1 expression. In addition, all macrophages did not have NFATc1 expression both in their nuclei and in their cytoplasm. Conclusion NFATc1 was suppressed both in Hodgkin cells and inflammatory cells surrounding the tumor cells. This condition may contribute to progressivity and aggressiveness of the diseases. Therefore, certain mechanisms to reactivate functional NFATc1 in HL tumor microenvironment may be necessary; hence, the tumor cells are able to be eradicated by patient's immune mechanisms. |
| Databáze: | OpenAIRE |
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