The Effectiveness of Diffusion Tensor Imaging in Determining Radiological Response after Radiosurgery in Patients with Vestibular Schwannoma
| Autor: | Lutfullah Sari, Alpay Alkan, Mustafa Aziz Hatiboglu, Dilek Hacer Cesme, Mehmet Hakan Seyithanoglu, Ahmet Kaya, Ismail Yurtsever, Gokberk Alkan |
|---|---|
| Přispěvatelé: | ALKAN, ALPAY |
| Rok vydání: | 2021 |
| Předmět: |
Vestibular system
business.industry medicine.medical_treatment Neuroma Acoustic Schwannoma Radiosurgery medicine.disease Magnetic Resonance Imaging Tumor Burden Diffusion Tensor Imaging Radiological weapon Fractional anisotropy medicine Humans Effective diffusion coefficient Radiology Nuclear Medicine and imaging In patient Cesme D. H. Alkan A. Sari L. Kaya A. Yurtsever I. Alkan G. Seyithanoglu M. H. Hatiboglu M. A. -The Effectiveness of Diffusion Tensor Imaging in Determining Radiological Response after Radiosurgery in Patients with Vestibular Schwannoma.- Current medical imaging 2021 Nuclear medicine business Diffusion MRI |
| Zdroj: | Current Medical Imaging Formerly Current Medical Imaging Reviews. 17:602-607 |
| ISSN: | 1573-4056 |
| Popis: | Background: The effectiveness of Diffusion Tensor Imaging (DTI) in demonstrating functional changes in the tumor in determining the response to treatment after radiosurgery in patients with vestibular schwannoma (VS) is not clear yet. Objective: The study aimed to determine the change total in tumor volume (TTV) in terms of radiological response in patients who had VS and were treated with radiosurgery and investigate the relationship between the TTV, follow-up times and DTI parameters. Methods: Thirty-one patients were assessed using DTI and MRI. TTV, apparent diffusion coefficient (ADC), and fractional anisotropy (FA) were calculated. Patients were divided into tree groups: those who responded to the treatment (group 1) (n=11), who did not (group 0) (n=9) and who remained stable (group 2) (n=11). Background: The effectiveness of Diffusion Tensor Imaging (DTI) in demonstrating functional changes in the tumor in determining the response to treatment after radiosurgery in patients with vestibular schwannoma (VS) is not clear yet. Objective: The study aimed to determine the change total in tumor volume (TTV) in terms of radiological response in patients who had VS and were treated with radiosurgery and investigate the relationship between the TTV, follow-up times and DTI parameters. Methods: Thirty-one patients were assessed using DTI and MRI. TTV, apparent diffusion coefficient (ADC), and fractional anisotropy (FA) were calculated. Patients were divided into tree groups: those who responded to the treatment (group 1) (n=11), who did not (group 0) (n=9) and who remained stable (group 2) (n=11). Results: The mean duration of follow-up was 28.81±14 months. ADC values increased in patients with VS after radiosurgery (p=0.004). There was no statistical difference in the FA values. A significant reduction in TTV after radiosurgery was detected in group 1 (p=0.003). ADC values increased significantly after radiosurgery in group 2 (p=0.04). Although there were no significant differences, ADC values after radiosurgery increased in group 1 and group 0. Conclusions: ADC values continuously increase due to radiation damage in the period before the tumor volume shrinks after radiosurgery. We think that it is not appropriate to diagnose inadequate treatment or progression only when TTV is evaluated in terms of response to treatment in the early period after radiosurgery. |
| Databáze: | OpenAIRE |
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