Intranasal oxygen reverses hypoxaemia in immobilised free-ranging capybaras (Hydrochoerus hydrochaeris)

Autor: Nathalia Villaça Xavier, Adriano Bonfim Carregaro, Mariana Cardoso Sanches, Jefferson F. Cordeiro, Elidiane Rusch, Åsa Fahlman, Ana Angélica Cassoli
Rok vydání: 2021
Předmět:
Physiology
Oxygen
Medicine and Health Sciences
Hypoxia
Flow Rate
education.field_of_study
Multidisciplinary
Pharmaceutics
Organic Compounds
Respiration
Physics
Monosaccharides
Classical Mechanics
Body Fluids
Chemistry
Blood
Breathing
Anesthesia
Physical Sciences
Arterial blood
Medicine
Anatomy
medicine.drug
Research Article
Chemical Elements
AGENTES DOPAMINÉRGICOS
Drug Administration
Butorphanol
Science
Partial Pressure
Population
Carbohydrates
chemistry.chemical_element
Rodentia
Pharmacology and Toxicology
Fluid Mechanics
Continuum Mechanics
Blood Plasma
Chemical restraint
Drug Therapy
medicine
Pressure
Animals
Dexmedetomidine
education
business.industry
Organic Chemistry
Chemical Compounds
Biology and Life Sciences
Fluid Dynamics
respiratory tract diseases
Glucose
chemistry
Midazolam
Nasal administration
business
Physiological Processes
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0260441 (2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
ISSN: 1932-6203
Popis: Capybara (Hydrochoerus hydrochaeris) is the main host of tick-borne pathogens causing Brazilian spotted fever; therefore, controlling its population is essential, and this may require chemical restraint. We assessed the impact of chemical restraint protocols on the partial pressure of arterial oxygen (PaO2) and other blood variables in 36 capybaras and the effect of different flows of nasal oxygen (O2) supplementation. The capybaras were hand-injected with dexmedetomidine (5 μg/kg) and midazolam (0.1 mg/kg) and butorphanol (0.2 mg/kg) (DMB, n = 18) or methadone (0.1 mg/kg) (DMM, n = 18). One-third of the animals were maintained in ambient air throughout the procedure, and one-third were administered intranasal 2 L/min O2 after 30 min whereas the other third were administered 5 L/min O2. Arterial blood gases, acid-base status, and electrolytes were assessed 30 and 60 min after drug injection. The DMB and DMM groups did not vary based on any of the evaluated variables. All animals developed hypoxaemia (PaO2 44 [30; 73] mmHg, SaO2 81 [62; 93] %) 30 min before O2 supplementation. Intranasal O2 at 2 L/min improved PaO2 (63 [49; 97] mmHg and SaO2 [92 [85; 98] %), but 9 of 12 capybaras remained hypoxaemic. A higher O2 flow of 5 L/min was efficient in treating hypoxaemia (PaO2 188 [146; 414] mmHg, SaO2 100 [99; 100] %) in all the 12 animals that received it. Both drug protocols induced hypoxaemia, which could be treated with intranasal oxygen supplementation.
Databáze: OpenAIRE
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