High Baseline Levels of Tumor Necrosis Factor Receptor 1 Are Associated With Progression of Kidney Disease in Indigenous Australians With Diabetes: The eGFR Follow-up Study
| Autor: | Federica Barzi, Kerin O'Dea, George Jerums, Graham R D Jones, Paul D. Lawton, Elif I Ekinci, Ashim Sinha, Mark Thomas, Wendy E. Hoy, Richard J MacIsaac, Elizabeth L M Barr, Louise J. Maple-Brown, Jaquelyne T. Hughes, Alan Cass, Alex Brown |
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| Přispěvatelé: | Barr, Elizabeth LM, Barzi, Federica, Hughes, Jaquelyne T, Jerums, George, Hoy, Wendy E, O'Dea, Kerin, Jones, Graham RD, Lawton, Paul D, Brown, Alex DH, Thomas, Mark, Ekinci, Elif I, Sinha, Ashim, Cass, Alan, MacIsaac, Richard J, Maple-Brown, Louise J |
| Rok vydání: | 2018 |
| Předmět: |
Male
Endocrinology Diabetes and Metabolism medicine.medical_treatment 030232 urology & nephrology markers population 030204 cardiovascular system & hematology chemistry.chemical_compound 0302 clinical medicine Medicine Diabetic Nephropathies Longitudinal Studies risk predict function decline Hazard ratio Middle Aged Renal Replacement Therapy Receptors Tumor Necrosis Factor Type I Disease Progression nephropathy Female Kidney Diseases medicine.symptom Glomerular Filtration Rate Adult medicine.medical_specialty Renal function Nephropathy 03 medical and health sciences Population Groups Internal medicine Diabetes mellitus Internal Medicine Albuminuria Humans Renal replacement therapy Aged Advanced and Specialized Nursing Creatinine business.industry Australia biomarkers esrd medicine.disease Diabetes Mellitus Type 2 chemistry inflammation ckd business Follow-Up Studies Kidney disease |
| Zdroj: | Diabetes Care. 41:739-747 |
| ISSN: | 1935-5548 0149-5992 |
| Popis: | OBJECTIVE To examine the association between soluble tumor necrosis factor receptor 1 (sTNFR1) levels and kidney disease progression in Indigenous Australians at high risk of kidney disease. RESEARCH DESIGN AND METHODS This longitudinal observational study examined participants aged ≥18 years recruited from >20 sites across diabetes and/or kidney function strata. Baseline measures included sTNFR1, serum creatinine, urine albumin-to-creatinine ratio (uACR), HbA1c, C-reactive protein (CRP), waist-to-hip ratio, systolic blood pressure, and medical history. Linear regression was used to estimate annual change in estimated glomerular filtration rate (eGFR) for increasing sTNFR1, and Cox proportional hazards were used to estimate the hazard ratio (HR) and 95% CI for developing a combined renal outcome (first of a ≥30% decline in eGFR with a follow-up eGFR RESULTS Over a median of 3 years, participants with diabetes (n = 194) in the highest compared with the lowest quartile of sTNFR1 experienced significantly greater eGFR decline (−4.22 mL/min/1.73 m2/year [95% CI −7.06 to −1.38]; P = 0.004), independent of baseline age, sex, eGFR, and uACR. The adjusted HR (95% CI) for participants with diabetes per doubling of sTNFR1 for the combined renal outcome (n = 32) was 3.8 (1.1–12.8; P = 0.03). No association between sTNFR1 and either renal outcome was observed for those without diabetes (n = 259). CONCLUSIONS sTNFR1 is associated with greater kidney disease progression independent of albuminuria and eGFR in Indigenous Australians with diabetes. Further research is required to assess whether TNFR1 operates independently of other metabolic factors associated with kidney disease progression. |
| Databáze: | OpenAIRE |
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