Predictors of Tadalafil Efficacy in Men with Erectile Dysfunction: The SURE Study Comparing Two Dosing Regimens
| Autor: | Sabine Weitckus, Jacques Buvat, Lucio Varanese, Helmut Petto, Pierre Costa, Simon Holmes, Karim Hamidi |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Phosphodiesterase Inhibitors Urology Endocrinology Diabetes and Metabolism Patient characteristics Pharmacology Drug Administration Schedule Tadalafil Endocrinology Erectile Dysfunction Disease severity Surveys and Questionnaires Internal medicine On demand medicine Humans Single-Blind Method Dosing Dose-Response Relationship Drug business.industry Penile Erection Coitus Middle Aged medicine.disease Psychiatry and Mental health Male Erectile Disorder Regimen Treatment Outcome Erectile dysfunction Reproductive Medicine Patient Satisfaction business Carbolines medicine.drug |
| Zdroj: | The Journal of Sexual Medicine. 3:1050-1058 |
| ISSN: | 1743-6095 |
| DOI: | 10.1111/j.1743-6109.2006.00330.x |
| Popis: | Introduction The efficacy of phosphodiesterase‐5 inhibitors in the treatment of erectile dysfunction may depend on patient characteristics. Aim To determine whether patient characteristics influence the efficacy of two tadalafil dosage regimens and to identify prognostic factors predictive of tadalafil efficacy. Methods This was a multicenter, open‐label study in which men with erectile dysfunction were randomized to tadalafil 20 mg either on demand or three times per week for a period of 5–6 weeks. After a 1‐week washout period, patients were crossed over to the alternate regimen for another 5–6 weeks. Main Outcome Measures Score of the Erectile Function (EF) domain of the International Index of Erectile Function Questionnaire (IIEF) and percentage of positive responses to questions 3 and 5 of the Sexual Encounter Profile (SEP) diary. Results A total of 4,262 patients were randomized. A normal EF domain score (≥26) at the end of on‐demand and three‐times‐per‐week treatment was reported by 60.2% and 62.3% of patients, respectively. The percentage of patients who achieved a normal EF domain score and the percentages reporting positive responses to SEP3 and SEP5 depended on the severity of erectile dysfunction and the presence of certain comorbidities, irrespective of the tadalafil dosage regimen. On regression analysis, the two best predictors of tadalafil efficacy were the baseline score of the IIEF‐EF domain and the baseline percentage of “Yes” responses to SEP2. Conclusions On‐demand and three‐times‐per‐week dosage regimens of tadalafil 20 mg were equally efficacious in men with erectile dysfunction. Among the possible prognostic factors tested in this study, baseline disease severity scores were the strongest predictors of efficacy endpoint scores. Costa P, Buvat J, Holmes S, Weitckus S, Petto H, Hamidi K, and Varanese L. Predictors of tadalafil efficacy in men with erectile dysfunction: The SURE study comparing two dosing regimens. J Sex Med 2006;3:1050–1058. |
| Databáze: | OpenAIRE |
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