Intervention Study on the Efficacy and Safety of Platycodon grandiflorus Ethanol Extract in Overweight or Moderately Obese Adults: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Trial
| Autor: | Ye Jin Kim, Jongbok Yun, Eun-Young Kwon, Manheun Kim, Young Mi Lee, Myung-Sook Choi, Ji Won Kim, Ri Ryu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Placebo-controlled study Renal function Adipokine lcsh:TX341-641 Platycodon grandiflorus Overweight Placebo Body fat percentage Gastroenterology 03 medical and health sciences BMI 0302 clinical medicine body fat mass Internal medicine medicine Platycodon grandiflorus root abdominal fat area Nutrition and Dietetics biology business.industry biology.organism_classification 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology medicine.symptom business Body mass index lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients Volume 11 Issue 10 Nutrients, Vol 11, Iss 10, p 2445 (2019) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu11102445 |
| Popis: | Platycodon grandiflorus root extract (PGE) has shown various properties, such as anti-hyperlipidemia, anti-diabetic, and anti-obesity, but mostly in animal studies. Therefore, we conducted a preliminary study on the anti-obesity effect of PGE in 108 Korean adults (aged 20&ndash 60 years, 30 kg/m2 &ge body mass index &ge 23 kg/m2). The participants were randomly assigned to four groups and were administered the placebo, PGE571 (571 mg as PGE), PGE1142 (1142 mg as PGE), and PGE2855 (2855 mg as PGE), independently, for 12 weeks. Body composition, nutrient intake, computed tomography scan, and plasma adipokines, as well as hepatic/renal function markers, were assessed. The PGE571 group revealed a significant decrease in body fat mass and body fat percentage when compared with the placebo group. Moreover, the total abdominal and subcutaneous fat areas were significantly decreased following PGE (PGE2855 group) supplementation. These results provide useful information on the anti-obesity effect of PGE for overweight and obese adult humans. |
| Databáze: | OpenAIRE |
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