Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post‐inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris
| Autor: | Célia Luiza Petersen Vitello Kalil, José Euzébio Gonçalves Junior, Priscila Correia, Luiza Helena Urso Pitassi, Valéria Campos, Beatriz Sant’Anna |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Dermatology Citric Acid Melanin 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound Follicle 0302 clinical medicine Acne Vulgaris medicine Humans Prospective Studies Acne Glycolic acid HEPES business.industry medicine.disease Hyperpigmentation Treatment Outcome chemistry 030220 oncology & carcinogenesis Female medicine.symptom Salicylic Acid business Citric acid Brazil Salicylic acid |
| Zdroj: | Journal of Cosmetic Dermatology. 20:1766-1773 |
| ISSN: | 1473-2165 1473-2130 |
| DOI: | 10.1111/jocd.14016 |
| Popis: | BACKGROUND Acne is a chronic disease that affects the pilosebaceous follicle and is characterized by the presence of non-inflammatory and/or inflammatory lesions, affecting both adolescents and adults. Inflammatory acne lesions are capable to increase their melanin production and promote a post-inflammatory hyperchromia. AIMS To assess the efficacy of a serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperpigmentation and controlling skin oiliness in Brazilian patients with acne vulgaris. PATIENTS/METHODS A single-center, prospective, open-label clinical study included 42 subjects, from both genders, presenting acne (grade I or II), oily skin and a clinical diagnosis of acne post-inflammatory hyperpigmentation. The study was conducted for 56 days, with clinical (skin quality and the number of post-inflammatory hyperchromic lesions) and instrumental (Sebumetry) evaluations after 7, 28, and 56 days of treatment. Standardized pictures were obtained using a VISIA-6® device. RESULTS A significant decrease in the grade of post-inflammatory hyperchromic lesions was observed after 28 and 56 days, while the number of lesions decreases by 29.4% after 56 days (p |
| Databáze: | OpenAIRE |
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