Interaction of the H63D Mutation in the Hemochromatosis Gene with the Apolipoprotein E Epsilon 4 Allele Modulates Age at Onset of Alzheimer’s Disease
| Autor: | Javier Llorca, Onofre Combarros, Jose L. Fernandez-Luna, Ana Fontalba, Jon Infante, José Berciano, Marisa García-Román |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Apolipoprotein E congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Genotype Cognitive Neuroscience Apolipoprotein E4 Sampling Studies Apolipoproteins E Degenerative disease Alzheimer Disease Risk Factors Internal medicine medicine Humans Age of Onset Risk factor Allele Hemochromatosis Aged Aged 80 and over business.industry nutritional and metabolic diseases Middle Aged medicine.disease Psychiatry and Mental health Endocrinology Mutation Mutation (genetic algorithm) Female Geriatrics and Gerontology Alzheimer's disease Age of onset business |
| Zdroj: | Dementia and Geriatric Cognitive Disorders. 15:151-154 |
| ISSN: | 1421-9824 1420-8008 |
| DOI: | 10.1159/000068480 |
| Popis: | The H63D mutation in the hemochromatosis gene (HFE) has recently been considered as a risk factor in Alzheimer`s disease (AD) with advancing age at onset of the disease, independently of the apolipoprotein E (ApoE) Ε4 allele effect. We examined the distribution of the H63D mutation and ApoE genotypes as a function of age at AD onset in 328 patients with sporadic AD. Our data show that the mutant H63D allele potentially interacts with the ApoE Ε4 allele to significantly reduce age at onset of AD compared to ApoE Ε4 carriers alone, but has no effect on age at onset in ApoE Ε4 non-carriers. |
| Databáze: | OpenAIRE |
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