Concordant and discordant adrenocorticotropin (ACTH) responses induced by growth hormone-releasing peptide-2 (GHRP-2), corticotropin-releasing hormone (CRH) and insulin-induced hypoglycemia in patients with hypothalamopituitary disorders: evidence for direct ACTH releasing activity of GHRP-2
| Autor: | Akira Shimatsu, Hiroshi Arimura, Michiyo Fukudome, Chuwa Tei, Hideki Mori, Akinori Tokitou, Takashi Kimura, Mitsuhiro Nakazaki |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Corticotropin-Releasing Hormone Endocrinology Diabetes and Metabolism Hypoglycemia Corticotropin-releasing hormone Endocrinology Adrenocorticotropic Hormone Internal medicine medicine Humans Insulin Secretion ACTH receptor Aged business.industry Insulin tolerance test Middle Aged medicine.disease Adrenal Cortex Function Tests Secretagogue Female business Oligopeptides hormones hormone substitutes and hormone antagonists Hypothalamic Diseases Hormone |
| Zdroj: | Endocrine journal. 57(7) |
| ISSN: | 1348-4540 |
| Popis: | The insulin-induced hypoglycemia test (insulin tolerance test: ITT) and corticotropin-releasing hormone (CRH) test are used to examine the activities of the hypothalamo-pituitary-adrenal (HPA) axis. Growth hormone-releasing peptide-2 (GHRP-2), a potent GH secretagogue, also stimulates adrenocorticotropin (ACTH) secretion. To evaluate the role of GHRP-2 in assessing the HPA axis, we examined 6 patients with various hypothalamo-pituitary disorders, and measured ACTH and cortisol responses during provocative tests (ITT, CRH, and GHRP-2 test). None of the 6 patients showed any significant ACTH or cortisol responses to ITT, but significant ACTH release was observed during CRH and GHRP-2 tests. These findings suggest GHRP-2 may directly stimulate ACTH secretion in patients with hypothalamo-pituitary disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|