Quantitative DWI predicts event-free survival in children with neuroblastic tumours: preliminary findings from a retrospective cohort study
| Autor: | Daniel Steinbach, Katharina Kneer, Holger Cario, Anna-Lydia Peschmann, Meinrad Beer, Bettina Ammann, Ambros J. Beer, Jens Dreyhaupt, Christian Beltinger, Henning Neubauer |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
medicine.medical_specialty Diffusion magnetic resonance imaging lcsh:R895-920 medicine.medical_treatment 030218 nuclear medicine & medical imaging 03 medical and health sciences Neuroblastoma 0302 clinical medicine medicine Effective diffusion coefficient Radiology Nuclear Medicine and imaging Ganglioneuroma Neuroradiology Ganglioneuroblastoma Chemotherapy medicine.diagnostic_test business.industry Retrospective cohort study Magnetic resonance imaging medicine.disease Confidence interval body regions Apparent diffusion coefficient Original Article Radiology business 030217 neurology & neurosurgery |
| Zdroj: | European Radiology Experimental European Radiology Experimental, Vol 3, Iss 1, Pp 1-10 (2019) |
| ISSN: | 2509-9280 |
| Popis: | Background Quantitative diffusion-weighted imaging (DWI) probes into tissue microstructure in solid tumours. In this retrospective ethically approved study, we investigated DWI as a potential non-invasive predictor of tumour dignity and prognosis in paediatric patients with neuroblastic tumours. Methods Nineteen consecutive patients with neuroblastoma (NB, n = 15), ganglioneuroblastoma (GNB, n = 1) and ganglioneuroma (GN, n = 3) underwent 3-T magnetic resonance imaging at first diagnosis and after 3-month follow-up, following a protocol including DWI (b = 50 and 800 s/mm2) in addition to standard sequences. All DWI scans were analysed for tumour volume assessment and apparent diffusion coefficient (ADC) calculation. Correlation with tumour pathology and risk factors (bone-marrow metastases, MYCN-amplification and 1p-deletion), therapeutic regime (observation versus chemotherapy) and clinical follow-up was evaluated. Results At baseline, mean ADC in NB was lower than in GNB/GN (0.76 vs. 1.47 × 10−3 mm2/s, p = 0.003). An ADC cutoff ≤ 1.05 identified malignant disease with 100.0% sensitivity (95% confidence interval [CI] 29.2–100.0%) and 93.8% specificity (95% CI 69.8–99.8%). Initial ADC was |
| Databáze: | OpenAIRE |
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