Normalization Time of Celiac Serology in Children on a Gluten-free Diet
| Autor: | Dominica Gidrewicz, Martha E. Lyon, J. Decker Butzner, Cynthia Trevenen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Adolescent Tissue transglutaminase Newly diagnosed Gastroenterology Serology 03 medical and health sciences Diet Gluten-Free 0302 clinical medicine Intestinal mucosa GTP-Binding Proteins 030225 pediatrics Internal medicine medicine Humans Protein Glutamine gamma Glutamyltransferase 2 Child Autoantibodies Retrospective Studies chemistry.chemical_classification Transglutaminases biology business.industry Autoantibody Retrospective cohort study Gluten Surgery Immunoglobulin A Celiac Disease Treatment Outcome chemistry Child Preschool Pediatrics Perinatology and Child Health biology.protein 030211 gastroenterology & hepatology Gluten free Female business Biomarkers Follow-Up Studies |
| Zdroj: | Journal of pediatric gastroenterology and nutrition. 64(3) |
| ISSN: | 1536-4801 |
| Popis: | Response to a gluten-free diet (GFD) in children with celiac disease is determined by symptom resolution and normalization of serology. We evaluated the rate of normalization of the transglutaminase (TTG) and antiendomysial (EMA) for children on a GFD after diagnosis. Celiac serologies were obtained over 3.5 years after starting a GFD in 228 newly diagnosed children with biopsy-proven celiac disease. Patients were classified into categories based on serology (group A, TTG ≥10 × upper limit of normal [ULN] and EMA ≥ 1:80; group B, TTG ≥10 × ULN and EMA ≤ 1:40; and group C, TTG 1 year in approximately 75% of GFD-compliant children with the highest celiac serology or most severe mucosal injury at diagnosis. Clinicians must consider serology and histology at diagnosis to properly evaluate response to GFD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text