Expression of gilt acts as a positive regulator of mouse hematopoietic progenitor cells
| Autor: | Hal E. Broxmeyer, Janice S. Blum, Scott Cooper |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Mice
Knockout CFU-GM Regulator Spleen Cell Biology Hematology Biology Hematopoietic Stem Cells Article Gene Expression Regulation Enzymologic Cell biology Mice Haematopoiesis medicine.anatomical_structure Immunity medicine Animals Molecular Medicine CFU-GEMM Oxidoreductases Acting on Sulfur Group Donors Bone marrow Progenitor cell Molecular Biology |
| Zdroj: | Blood Cells Mol Dis |
| ISSN: | 1079-9796 |
| DOI: | 10.1016/j.bcmd.2021.102574 |
| Popis: | Gamma interferon inducible lysosomal thiol reductase (GILT), is known to be involved in immunity, but its role in hematopoiesis has not been previously reported. Herein, we demonstrate using gilt knockout (-/-) mice that loss of gilt associates with decreased numbers and cycling status of femoral hematopoietic progenitor cells (CFU-GM, BFU-E, and CFU-GEMM) with more modest effects on splenic progenitor cells. Thus, GILT is associated with positive regulation of hematopoietic progenitor cells in mice, mainly in bone marrow. |
| Databáze: | OpenAIRE |
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