Vasoactive intestinal polypeptide: Presence in neuroblastoma × glioma hybrid cells
| Autor: | Jacqueline Besson, Gabriel Rosselin, Bernd Hamprecht, Thomas Glaser |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
medicine.medical_specialty
Vasoactive intestinal peptide Hybrid Cells Cell Line Gastrointestinal Hormones Neuroblastoma cell Mice Neuroblastoma Glioma Internal medicine medicine Animals neoplasms Cells Cultured Pharmacology Chemistry Radioimmunoassay Neoplasms Experimental medicine.disease Molecular biology Rats Endocrinology Neurohormones hormones hormone substitutes and hormone antagonists Function (biology) Acetylcholine Vasoactive Intestinal Peptide medicine.drug |
| Zdroj: | European Journal of Pharmacology. 90:121-123 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(83)90222-4 |
| Popis: | Extracts of neuroblastoma × glioma hybrid cells 108CC15 and their parental lines were investigated for the presence of vasoactive intestinal polypeptide (VIP). With the aid of a radioimmunoassay and a receptor binding assay, VIP activity was found in the hybrid cells, to a lesser extent in neuroblastoma cells, but not in glioma cells, but not in glioma cells. These results suggest a neuronal function of VIP. Since the hybrid cells also contain acetylcholine and opioids, they may be useful in studies of co-release of neurohormones. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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