Decreased Glomerular Proteinase Activity in the Streptozotocin Diabetic Rat
| Autor: | Ruo H. Song, Ashok Kumar Singh, David J. Leehey |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Renal glomerulus medicine.medical_treatment Kidney Glomerulus Cathepsin B Diabetes Mellitus Experimental Rats Sprague-Dawley Diabetes mellitus Internal medicine Animals Medicine Collagenases Mesangial cell business.industry Insulin medicine.disease Streptozotocin Rats Endocrinology Nephrology Collagenase Interstitial collagenase business medicine.drug |
| Zdroj: | American Journal of Nephrology. 19:441-446 |
| ISSN: | 1421-9670 0250-8095 |
| DOI: | 10.1159/000013492 |
| Popis: | Decreased glomerular proteinase activity may contribute to matrix accumulation in diabetes. Male Sprague-Dawley rats were rendered diabetic by injection of streptozotocin (STZ) 65 mg/kg i.v.; age-matched, sham-injected rats served as controls. Glomeruli from diabetic rats 1 month after STZ injection demonstrated significant decreases in collagenase and cathepsin B activities compared to control glomeruli. Treatment with insulin resulted in a slight (but not significant) increase in collagenase activity and normalized cathepsin B activity. We conclude that decreased glomerular collagenase and cathepsin B activities are present in STZ diabetes. These alterations may contribute to mesangial matrix accumulation. |
| Databáze: | OpenAIRE |
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