Screw-actuated displacement micropumps for thermoplastic microfluidics
| Autor: | Omid Rahmanian, Don L. DeVoe, Jung Yeon Han, Eric L. Kendall, N. Fleming |
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| Rok vydání: | 2016 |
| Předmět: |
Fabrication
Thermoplastic Materials science Microfluidics Biomedical Engineering Mechanical engineering Bioengineering Hardware_PERFORMANCEANDRELIABILITY 02 engineering and technology 01 natural sciences Biochemistry Lab-On-A-Chip Devices Hardware_INTEGRATEDCIRCUITS Electronic engineering Leakage (electronics) chemistry.chemical_classification 010401 analytical chemistry Temperature General Chemistry Equipment Design 021001 nanoscience & nanotechnology 0104 chemical sciences Volumetric flow rate Microcontroller Flow control (fluid) chemistry High pressure 0210 nano-technology Plastics Software |
| Zdroj: | Lab on a chip. 16(20) |
| ISSN: | 1473-0189 |
| Popis: | The fabrication of on-chip displacement pumps integrated into thermoplastic chips is explored as a simple and low cost method for achieving precise and programmable flow control for disposable microfluidic systems. The displacement pumps consist of stainless steel screws inserted into threaded ports machined into a thermoplastic substrate which also serve as on-chip reagent storage reservoirs. Three different methods for pump sealing are investigated to enable high pressure flows without leakage, and software-defined control of multiple pumps is demonstrated in a self-contained platform using a compact and self-contained microcontroller for operation. Using this system, flow rates ranging from 0.5–40 μl min−1 are demonstrated. The pumps are combined with on-chip burst valves to fully seal multiple reagents into fabricated chips while providing on-demand fluid distribution in a downstream microfluidic network, and demonstrated for the generation of size-tunable water-in-oil emulsions. |
| Databáze: | OpenAIRE |
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