The effects of varying fluid volume and rate of resuscitation during uncontrolled hemorrhage
| Autor: | Illner H, G. Tom Shires, Wen C. Hsia, Dana M. Soucy, Malcolm Rude, Fred N. Hagedorn |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Resuscitation
Time Factors Rate of infusion Improved survival Shock Hemorrhagic Sodium Chloride Rats Sprague-Dawley medicine Animals Survival rate business.industry Hemodynamics Survival Analysis Rats Disease Models Animal Volume (thermodynamics) Hematocrit Anesthesia Shock (circulatory) Prothrombin Time Fluid Therapy Female Partial Thromboplastin Time medicine.symptom Isotonic Solutions business Perfusion Fluid volume |
| Zdroj: | The Journal of trauma. 46(2) |
| ISSN: | 0022-5282 |
| Popis: | Background: The role of rate and volume of infusion in survival from experimental uncontrolled hemorrhage was evaluated. Methods: Hemorrhage was initiated using tail resection in 43 female rats assigned to the following five groups: nonresuscitated ; resuscitated with moderate volume, slower rate; resuscitated with moderate volume, faster rate; resuscitated with high volume, slower rate; and resuscitated with high volume, faster rate. Results: A trend toward improved survival was noted with faster rate of infusion (60 vs. 33.3% survival rate with moderate volume and 28.6 vs. 12.5% with high volume, compared with 16.7% in the nonresuscitated animals). Conclusion: Rapid infusion of moderate volume of isotonic saline improved survival in uncontrolled hemorrhage. Extreme volumes, infused rapidly, also resulted in higher survival rates compared with those observed in nonresuscitated rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|