A new destruxin as inhibitor of vacuolar-type H+-ATPase of Saccharomyces cerevisiae
| Autor: | Alfonso Espada, Juan A. Hueso-Rodríguez, María I. Albarrán, Alfonso Rivera-Sagredo, María Jesús Vázquez, E. Diez |
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| Rok vydání: | 2006 |
| Předmět: |
Metarhizium
Vacuolar Proton-Translocating ATPases Time Factors ATPase Saccharomyces cerevisiae Metarhizium anisopliae Osteoclasts Bioengineering Fungus Biochemistry Microbiology Inhibitory Concentration 50 Depsipeptides Structural isomer Animals Molecular Biology biology Dose-Response Relationship Drug Molecular Structure Chemistry General Chemistry General Medicine biology.organism_classification Small molecule Destruxin E Fermentation biology.protein Molecular Medicine Chickens |
| Zdroj: | Chemistrybiodiversity. 2(1) |
| ISSN: | 1612-1880 |
| Popis: | In the course of our screening efforts to discover small molecules as selective inhibitors of vacuolar-type H + -ATPase of Saccharomyces cerevisiae, we have identified eight active destruxins, 1-8, from the fungus Metarhizium anisopliae. The structures were elucidated by extensive 1D- and 2D-NMR spectroscopy, and MS spectrometry. One of these compounds, 8, a regioisomer of chlorohydrin destruxin E (7), is a new destruxin. |
| Databáze: | OpenAIRE |
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