Study protocol for the follow-up examination of the Nor-Hand study: A hospital-based observational cohort study exploring pain and biomarkers in people with hand osteoarthritis
| Autor: | Sarah Ohrndorf, Alexander Mathiessen, M. Gløersen, Ida K. Haugen, Pernille Steen Pettersen, Ø. Maugesten, Tuhina Neogi, Karwan Faraj, E. Mulrooney, Dag Sjølie, Tore K Kvien, Barbara Slatkowsky-Christensen, Heidi Gammelsrud, Hilde Berner Hammer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Biopsychosocial model
Protocol (science) medicine.medical_specialty medicine.diagnostic_test business.industry Follow up examination Pain Magnetic resonance imaging Disease Hospital based Diseases of the musculoskeletal system Outcome measures Imaging RC925-935 Hand osteoarthritis medicine Physical therapy business Cohort study |
| Zdroj: | Osteoarthritis and Cartilage Open, Vol 3, Iss 3, Pp 100198-(2021) |
| ISSN: | 2665-9131 |
| Popis: | Objective This study aims to increase the understanding of pain mechanisms in hand OA and explore potential risk factors for pain development or worsening in a biopsychosocial framework. Another important aim is to validate potential soluble and imaging OA biomarkers. Design The follow-up examination of the Nor-Hand hospital-based observational cohort study started in October 2019 and was completed in May 2021. In total, 212 of the 300 participants with hand OA who were examined at baseline attended the follow-up study. The participants underwent clinical joint examinations, medical and functional assessments, quantitative sensory testing, fluorescence optical imaging, ultrasound of the hands, acromioclavicular joints, feet, knees and hips, conventional radiographs of the hands and feet and magnetic resonance imaging of the dominant hand. Blood and urine samples were collected, and all participants answered questions about demographic factors and OA-related questionnaires. Associations between disease variables and symptoms will be examined in cross-sectional and longitudinal analyses. Longitudinal analyses will be performed to assess the predictive value of baseline variables on hand OA outcomes. Conclusion Current knowledge about predictors for disease progression in hand OA is limited, but with longitudinal data we will be able to explore the predictive value of baseline variables on hand OA outcomes, such as changes in patient-reported outcomes or changes in soluble and imaging biomarkers. This provides a unique opportunity to gain more knowledge about the natural disease course of hand OA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|