The framework for population epigenetic study
| Autor: | Linna Zhao, Jing Xu, Ying Li, Yongshuai Jiang, Guiyou Liu, Changgui Lei, Yang Chen, Zhaoyang Wang, Di Liu |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Linkage disequilibrium Population Black People Population genetics Single-nucleotide polymorphism HapMap Project Biology Polymorphism Single Nucleotide Linkage Disequilibrium White People Epigenesis Genetic 03 medical and health sciences Humans Lymphocytes Allele International HapMap Project education Molecular Biology Allele frequency Alleles Cells Cultured Genetics education.field_of_study Haplotype DNA Methylation Genetics Population 030104 developmental biology Haplotypes Information Systems |
| Zdroj: | Briefings in Bioinformatics. :bbw098 |
| ISSN: | 1477-4054 1467-5463 |
| Popis: | At present, understanding of DNA methylation at the population level is still limited. Here, we first extended the classical framework of population genetics, such as single nucleotide polymorphism allele frequency, linkage disequilibrium (LD), LD block and haplotype, to epigenetics. Then, as an example, we compared the DNA methylation disequilibrium (MD) maps between HapMap CEU (Caucasian residents of European ancestry from Utah) population and YRI (Yoruba people from Ibadan) population (lymphoblastoid cell lines). We analyzed the differences and similarities between CEU and YRI from the following aspects: SMP (single methylation polymorphism) allele frequency, SMP allele association, MD, MD block and methylation haplotype (meplotype) frequency. The results showed that CEU and YRI had similar distribution of SMP allele frequency, and shared many MD block region. We believe that the framework of population genetics can be used in the population epigenetics. The population epigenetic framework also has potential prospects in the study of complex diseases, such as epigenome-wide association study. |
| Databáze: | OpenAIRE |
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