TUSARC: Prognostic Value of High-Sensitivity Cardiac Troponin T Assay in Asymptomatic Patients with High Cardiovascular Risk
| Autor: | Vicente Villamandos, Diego Martín Raymondi, Héctor García, Luis Hernández, Jorge Palazuelos Molinero, Isabel Álvarez |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Population 030204 cardiovascular system & hematology Risk Assessment Asymptomatic 03 medical and health sciences 0302 clinical medicine Troponin T Predictive Value of Tests Risk Factors Internal medicine medicine Humans Registries 030212 general & internal medicine Myocardial infarction Prospective cohort study education Aged Heart Failure education.field_of_study business.industry Incidence Incidence (epidemiology) General Medicine Middle Aged Prognosis medicine.disease Coronary revascularization Cardiovascular Diseases Spain Heart failure Cardiology Female High-Sensitivity Cardiac Troponin T Assay medicine.symptom business Biomarkers |
| Zdroj: | The American Journal of Medicine. 132:631-638 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/j.amjmed.2018.11.035 |
| Popis: | Prognostic value of high-sensitivity cardiac troponin T (hs-cTnT) assays have been assessed in selected populations in different studies and in registries of members of the general population with low cardiovascular risk. The aim of this study was to determine the prognostic value of hs-cTnT in an asymptomatic very-high cardiovascular risk Spanish population.From a previous prospective cohort of the TUSARC (troponina T UltraSensible en pacientes Asintomáticos de alto Riesgo Cardiovascular) registry, follow-up was conducted in 602 patients (93.18%). The association of high hs-cTnT (≥99th percentile value) and incidence of primary event was studied. A primary event was defined as a combined major cardiovascular event (incidence of cardiovascular death, decompensated heart failure, non-fatal cerebrovascular event, non-fatal myocardial infarction, or coronary revascularization). The association between high hs-cTnT and incidence of secondary events was studied as well.In patients with high hs-cTnT, the incidence of primary event during follow-up was significantly higher (18.30% vs 3.67% P.001): heart failure (6.25% vs 0.73% P.001), cardiovascular death (7.29% vs 0.00% P.001), and death from any cause (7.81% vs 0.98% P.001).In an asymptomatic very-high cardiovascular risk Spanish population, elevated hs-cTnT was significantly associated with incident major cardiovascular combined end point and incidence of heart failure, cardiovascular death, and death from any cause. |
| Databáze: | OpenAIRE |
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