Induction of ovulation with the use of a starting dose of 50 units of recombinant human follicle-stimulating hormone (Puregon∗)
| Autor: | Adam H. Balen, Catherine J. Hayden, Anthony J. Rutherford |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty medicine.drug_class medicine.medical_treatment media_common.quotation_subject Drug Resistance Biology Clomiphene Follicle-stimulating hormone Ovarian Follicle Ovulation Induction Clomifene Follicular phase medicine Humans Prospective Studies Ovulation Retrospective Studies media_common Gynecology Estradiol Polycystic ovary syndrome (PCOS) Obstetrics and Gynecology Fertility Agents Female medicine.disease Polycystic ovary Recombinant Proteins Stimulation Chemical Reproductive Medicine Female Follicle Stimulating Hormone Human Ovulation induction Follicle Stimulating Hormone Gonadotropin Polycystic Ovary Syndrome medicine.drug |
| Zdroj: | Fertility and Sterility. 71:106-108 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(98)00408-7 |
| Popis: | Objective: To determine whether a starting dose of 50 units of recombinant FSH (follitropin beta, Puregon; Organon Laboratories Limited, Cambridge, United Kingdom) produces a follicular response in patients with clomiphene citrate–resistant polycystic ovary syndrome (PCOS). Design: Prospective observational study. Setting: Routine clinical practice in a teaching hospital fertility unit. Patient(s): Patients with clomiphene citrate–resistant PCOS who wanted to become pregnant. Intervention(s): Low-dose step-up protocol of SC recombinant FSH administration, monitored prospectively by transvaginal ultrasonography and retrospectively by serum endocrine assays taken at each monitoring visit. Main outcome measure(s): Rate and size of follicular growth, recombinant FSH requirement, E 2 response, ovulation, cycle cancellation, and pregnancy. Result(s): All patients exhibited a follicular response: Six patients ovulated, of whom two conceived and four had their cycles cancelled because of overstimulation. One patient did not ovulate despite the development of a follicle. Conclusion(s): Recombinant FSH can be used successfully to stimulate follicular growth at a starting dose of 50 IU. |
| Databáze: | OpenAIRE |
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