Effects of Iopamidol-370 Versus Iodixanol-320 on Coronary Contrast, Branch Depiction, and Heart Rate Variability in Dual-Source Coronary MDCT Angiography
| Autor: | Laura T. Meyer, Jared D. Christensen, Daniel T. Boll, Lynne M. Hurwitz |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Chest Pain medicine.medical_specialty media_common.quotation_subject Cardiac-Gated Imaging Techniques Contrast Media Coronary Angiography Iopamidol Heart Rate Triiodobenzoic Acids Internal medicine Heart rate medicine Humans Contrast (vision) Heart rate variability Dual source Radiology Nuclear Medicine and imaging Prospective Studies Aged media_common Aged 80 and over business.industry General Medicine Middle Aged Coronary arteries medicine.anatomical_structure Cohort Cardiology Female Radiology Tomography X-Ray Computed business Student's t-test medicine.drug |
| Zdroj: | American Journal of Roentgenology. 197:W445-W451 |
| ISSN: | 1546-3141 0361-803X |
| DOI: | 10.2214/ajr.10.6154 |
| Popis: | The purpose of this article is to assess whether iopamidol-370 provides superior vascular contrast of the coronaries and depiction of anatomic detail without affecting heart rate and beat-to-beat variability during coronary dual-source MDCT compared with iodixanol-320.In this prospective trial, coronary CT angiography was performed on 60 adult patients using either iopamidol-370 or iodixanol-320. Cohorts were matched by age, habitus, sex, and baseline heart rate, with cohort sizes determined by power analysis. All studies were performed on a dual-source MDCT scanner with retrospective ECG-gating utilizing automatic pitch adjustment. Data assessment focused on heart rate variability during contrast administration statistically evaluated as Student t test comparisons within and between cohorts, coronary contrast-to-noise ratio analysis of the main coronary arteries utilizing Student t test comparisons between cohorts, and coronary branch depiction and distribution analysis in dual-reader consensus decisions between cohorts.Thirty patients matched for age, habitus, sex, and heart rate were evaluated in each cohort. ECG analyses found a statistically significant (p = 0.013) decrease in heart rate during administration of iodixanol-320. Beat-to-beat variations, expressed as coefficient of variation, within and among cohorts were low (coefficient of variation,0.05). Contrast-to-noise ratio was significantly increased for iopamidol-370 versus iodixanol-320 (aortic root, p = 0.021; left main, p = 0.032; left anterior descending, p = 0.033; left circumflex, p = 0.039; and right, p = 0.009). Analysis of coronary branch visualization revealed improved depiction for iopamidol-370 compared with iodixanol-320.Iopamidol-370, with its higher iodine concentration, provided greater vascular contrast of the arterial coronary tree and improved depiction of anatomic detail without significantly impacting cardiac heart rate during coronary MDCT imaging, as compared with iodixanol-320. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|