Distribution of Bungarus multicinctus venom following envenomation
| Autor: | C.Y. Lee, L.F. Tseng |
|---|---|
| Rok vydání: | 1966 |
| Předmět: |
Respiratory Tract Diseases
Venom Spleen Pharmacology Biology Toxicology Kidney complex mixtures Bungarus Mice Cerebrospinal fluid Iodine Isotopes medicine Bioassay Animals Intestinal Mucosa Envenomation Radiometry Lung Venoms Stomach Muscles Myocardium Skeletal muscle Snakes biology.organism_classification medicine.anatomical_structure Gastric Mucosa Immunology Injections Intravenous Chromatography Gel Autoradiography Biological Assay Rabbits |
| Zdroj: | Toxicon : official journal of the International Society on Toxinology. 3(4) |
| ISSN: | 0041-0101 |
| Popis: | The distribution of the venom of Bungarus multicinctus and its purified toxins (α- and β-Bungarotoxin) in animals has been studied either by bioassay method or using I131-labeled preparations. Although radioactivity could be detected in the cerebrospinal fluid (CSF) of rabbits after intravenous injection of 1 mg per kg of the venom or the toxins, the CSF levels were too low to account for the rapid respiratory paralysis. No measurable amounts of the venom were found in the CSF by the bioassay method at this dose level. The highest radioactivity was found in kidneys, followed in decreasing order by lungs, spleen, heart, stomach, intestine, diaphragm and skeletal muscle, with the lowest in the brain. In mice, injected subcutaneously with 2 ld50 of the venom or the Bungarotoxins, similar distribution patterns were found, except for much higher radioactivity in the stomach. α-Bungarotoxin was found to localize on the end-plate zone of the mouse diaphragm, whereas β-Bungarotoxin did not show such localization. |
| Databáze: | OpenAIRE |
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