Urinary Cyclic AMP in ‘Endogenous' and ‘Neurotic’ Depression
| Autor: | Kenneth Sinanan, Athene M. B. Keatinge, W. Clayton Love, P. G. S. Beckett |
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| Rok vydání: | 1975 |
| Předmět: |
Adult
Male Self-Assessment medicine.medical_specialty Adolescent Urinary system Physical Exertion Remission Spontaneous Urination Endogeny Diagnosis Differential Excretion Adjustment Disorders 03 medical and health sciences 0302 clinical medicine Internal medicine Cyclic AMP medicine Humans In patient 030212 general & internal medicine Neurotic Depression Depression (differential diagnoses) Depression Middle Aged Control subjects 030227 psychiatry Psychiatry and Mental health Endocrinology Creatinine Endogenous depression Female Psychology |
| Zdroj: | British Journal of Psychiatry. 126:49-55 |
| ISSN: | 1472-1465 0007-1250 |
| DOI: | 10.1192/bjp.126.1.49 |
| Popis: | Since the discovery of adenosine 3'5'-cyclic monophosphate (cyclic AMP) by Sutherland and Rall (1958), the concept has evolved that this nucleotide acts as the second messenger substance for many neurotransmitter and hormone-induced responses (Sutherland, Robison and Butcher, 1968). Cyclic AMP occurs in high concentration in the brain. Cyclic AMP is functionally closely related, and possibly fundamental, to the action of catecholamines and serotonin, both of which have been implicated in the amine hypothesis of depression (Granville-Grossman, 1971). Cyclic AMP is formed from ATP by the action of an enzyme adenyl cyclase, and it is degraded by the enzyme cyclic-AMP-phosphodiesterase(Lancet, Editorial, 1970) both of which occur in brain. |
| Databáze: | OpenAIRE |
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