Sodium Homeostasis in Chronic Kidney Disease
| Autor: | Jerry Yee, Vivek Soi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Nephrotic Syndrome Sympathetic Nervous System Vasopressins Sodium Population 030232 urology & nephrology Volume overload chemistry.chemical_element 030204 cardiovascular system & hematology urologic and male genital diseases Renin-Angiotensin System 03 medical and health sciences 0302 clinical medicine Internal medicine Renin–angiotensin system medicine Animals Homeostasis Humans Renal Insufficiency Chronic education Skin education.field_of_study Kidney business.industry Diet Sodium-Restricted medicine.disease female genital diseases and pregnancy complications Oxidative Stress Endocrinology medicine.anatomical_structure chemistry Nephrology Hypertension business Nephrotic syndrome Atrial Natriuretic Factor Kidney disease |
| Zdroj: | Advances in Chronic Kidney Disease. 24:325-331 |
| ISSN: | 1548-5595 |
| Popis: | The pathologic consequences of sodium retention in the CKD population can lead to hypertension, edema, and progressive disease. Sodium excess is responsible for increases in oxidative stress, which alters kidney vasculature. As progression of CKD occurs, hyperfiltration by remaining nephrons compensates for an overall decrease in the filtered load of sodium. In the later stages of CKD, compensatory mechanisms are overcome and volume overload ensues. Nephrotic syndrome as it relates to sodium handling involves a different pathophysiology despite a common phenotype. Extrarenal sodium buffering is also examined as it has significant implications in the setting of advanced CKD. |
| Databáze: | OpenAIRE |
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