Early-response multiple-parameter biodosimetry and dosimetry: risk predictions

Autor: Matthias Port, Michael Abend, William F. Blakely
Rok vydání: 2021
Předmět:
Proteomics
medicine.medical_specialty
biodosimetry
Blutbild
blood chemistry
Blood
Radiation effects
Biodosimetry
Humans
Medicine
Dosimetry
Nuklearmedizin
Sampling (medicine)
ddc:610
cytogenetic dose assessment
acute radiation syndrome (ARS) severity
Blood chemical analysis
Radiation Injuries
Radiometry
Acute radiation syndrome
Waste Management and Disposal
radioactivity contamination
Chromosome Aberrations
Strahlendosis
business.industry
Public Health
Environmental and Occupational Health
General Medicine
Gold standard (test)
Integrated approach
Cytogenetic analysis
Methods
Triage
Radioactivity
Dose-response relationship
Radiation
Blood chemistry
Radiological weapon
Nuclear medicine
Analysis
physical dosimetry
clinical signs and symptoms
Dosimetrie
Radiology
business
DDC 610 / Medicine & health
Zdroj: Journal of Radiological Protection. 41:R152-R175
ISSN: 1361-6498
0952-4746
DOI: 10.1088/1361-6498/ac15df
Popis: The accepted generic multiple-parameter and early-response biodosimetry and dosimetry assessment approach for suspected high-dose radiation (i.e. life-threatening) exposure includes measuring radioactivity associated with the exposed individual (if appropriate); observing and recording prodromal signs/symptoms; obtaining serial complete blood counts with white-blood-cell differential; sampling blood for the chromosome-aberration cytogenetic bioassay using the ‘gold standard’ dicentric assay (premature chromosome condensation assay for exposures >5 Gy photon acute doses equivalent), measurement of proteomic biomarkers and gene expression assays for dose assessment; bioassay sampling, if appropriate, to determine radioactive internal contamination; physical dose reconstruction, and using other available opportunistic dosimetry approaches. Biodosimetry and dosimetry resources are identified and should be setup in advance along with agreements to access additional national, regional, and international resources. This multifaceted capability needs to be integrated into a biodosimetry/dosimetry ‘concept of operations’ for use in a radiological emergency. The combined use of traditional biological-, clinical-, and physical-dosimetry should be use in an integrated approach to provide: (a) early-phase diagnostics to guide the development of initial medical-management strategy, and (b) intermediate and definitive assessment of radiation dose and injury. Use of early-phase (a) clinical signs and symptoms, (b) blood chemistry biomarkers, and (c) triage cytogenetics shows diagnostic utility to predict acute radiation injury severity.
publishedVersion
Databáze: OpenAIRE
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