Antiviral Activity of Ribosome-Inactivating Proteins

Autor: Rosario Iglesias, José Miguel Ferreras, Lucía Citores
Jazyk: angličtina
Rok vydání: 2021
Předmět:
2420 Virología
Health
Toxicology and Mutagenesis
Ribosome Inactivating Proteins
lcsh:Medicine
adenine polynucleotide glycosylase
Plantas transgénicas resistentes a virus
Plantas Transgénicas
Review
Toxicology
Ribosome
Ribosomes - Structure
Plantas - Biotecnología
antiviral therapy
Protein biosynthesis
virus-resistant transgenic plant (VRTP)
Protein Synthesis Inhibitors
0303 health sciences
Proteins - Synthesis
030302 biochemistry & molecular biology
Plants
Genetically Modified
Virus
immunotoxin
Virus Diseases
Viruses
Proteínas inactivadoras de ribosomas
human virus
2019-20 coronavirus outbreak
2412 Inmunología
Virus-resistant transgenic plant
Immunology
Biology
Antiviral Agents
03 medical and health sciences
2302 Bioquímica
Virology
rRNA glycosylase (EC 3.2.2.22)
Animals
Humans
Pest Control
Biological
030304 developmental biology
Plant Diseases
Toxins
Biological
Virus - Tratamiento
Ribosome-inactivating protein
lcsh:R
Ribosomal RNA
Proteínas
rRNA glycosylase
Research studies
ribosome-inactivating protein (RIP)
Human Virus
Zdroj: Toxins
Toxins, Vol 13, Iss 80, p 80 (2021)
ISSN: 2072-6651
Popis: Producción Científica
Ribosome-inactivating proteins (RIPs) are rRNA N-glycosylases from plants (EC 3.2.2.22) that inactivate ribosomes thus inhibiting protein synthesis. The antiviral properties of RIPs have been investigated for more than four decades. However, interest in these proteins is rising due to the emergence of infectious diseases caused by new viruses and the difficulty in treating viral infections. On the other hand, there is a growing need to control crop diseases without resorting to the use of phytosanitary products which are very harmful to the environment and in this respect, RIPs have been shown as a promising tool that can be used to obtain transgenic plants resistant to viruses. The way in which RIPs exert their antiviral effect continues to be the subject of intense research and several mechanisms of action have been proposed. The purpose of this review is to examine the research studies that deal with this matter, placing special emphasis on the most recent findings.
Junta de Castilla y León - (Grant VA033G19)
Databáze: OpenAIRE
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