Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model
| Autor: | Claire Fabian, Samantha Swarbrick, Marie-Christine Pardon, Alexandra Stolzing, Christiane Leovsky, Luís Costa-Marques, Katrin Arnold |
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| Přispěvatelé: | Publica |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Amyloid beta Cognitive Neuroscience amyloid-v Hippocampus lcsh:RC346-429 Cell therapy 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Neuroinflammation Medicine Interleukin 6 lcsh:Neurology. Diseases of the nervous system Microglia biology business.industry Research Alzheimer's disease Transplantation Interleukin 10 030104 developmental biology medicine.anatomical_structure Mikroglia biology.protein Zelltherapie Neurology (clinical) Bone marrow business Alzheimer’s disease 030217 neurology & neurosurgery |
| Zdroj: | Translational Neurodegeneration Translational Neurodegeneration, Vol 8, Iss 1, Pp 1-11 (2019) |
| ISSN: | 2047-9158 |
| DOI: | 10.1186/s40035-019-0173-9 |
| Popis: | Background We investigated early hallmarks of putative therapeutic effects following systemic transplantation of bone marrow derived macrophages (BM-M) in APP/PS1 transgenic mice. Method BM-M were transplanted into the tail vein and the animals analysed 1 month later. Results BM-M transplantation promoted the reduction of the amyloid beta [37-42] plaque number and size in the cortex and hippocampus of the treated mice, but no change in the more heavily modified pyroglutamate amyloid beta E3 plaques. The number of phenotypically ‘small’ microglia increased in the hippocampus. Astrocyte size decreased overall, indicating a reduction of activated astrocytes. Gene expression of interleukin 6 and 10, interferon-gamma, and prostaglandin E receptor 2 was significantly lower in the hippocampus, while interleukin 10 expression was elevated in the cortex of the treated mice. Conclusions BM-M systemically transplanted, promote a decrease in neuroinflammation and a limited reversion of amyloid pathology. This exploratory study may support the potential of BM-M or microglia-like cell therapy and further illuminates the mechanisms of action associated with such transplants. |
| Databáze: | OpenAIRE |
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