MS-681a, b, c and d, new inhibitors of myosin light chain kinase from Myrothecium sp. II. Physico-chemical properties and structure elucidation
| Autor: | Bando Chieko, Yoji Ikuina, Hiroshi Yano, Yutaka Saitoh, Mayumi Yoshida |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Myosin light-chain kinase Magnetic Resonance Spectroscopy biology Stereochemistry Spermidine Chemical synthesis Amino acid chemistry.chemical_compound Enzyme chemistry Enzyme inhibitor Drug Discovery Hypocreales biology.protein Polyamines Moiety Enzyme Inhibitors Polyamine Peptides Myosin-Light-Chain Kinase Myrothecium sp |
| Zdroj: | The Journal of antibiotics. 50(12) |
| ISSN: | 0021-8820 |
| Popis: | MS-681a, b, c and d are new inhibitors of myosin light chain kinase produced by Myrothecium sp. They are novel octapeptides containing alpha-alkyl-alpha-amino acids and a polyamine moiety. The structures were determined by NMR and FAB-MS/MS spectral analyses of the intact peptides. Their absolute configurations were elucidated by GC analysis on a chiral column of the constituent amino acids and by chemical synthesis of the polyamine moieties. |
| Databáze: | OpenAIRE |
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