Injectable macromolecule-based calcium phosphate bone substitutes
| Autor: | Hilel Moussi, Pierre Weiss, Jean Le Bideau, Hélène Gautier, Baptiste Charbonnier |
|---|---|
| Přispěvatelé: | BASCHERA, Richard, Institut des Matériaux Jean Rouxel (IMN), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - Ecole Polytechnique de l'Université de Nantes (Nantes Univ - EPUN), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Regenerative Medicine and Skeleton (RMeS), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR Odontologie, Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
GELATIN
IN-VITRO SCAFFOLDS [PHYS.COND.CM-MS] Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] HYDROXYPROPYL METHYLCELLULOSE BIOMATERIAL Chemistry (miscellaneous) REGENERATION SURGICAL-TREATMENT CEMENT COMPOSITES [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci] General Materials Science CHITOSAN |
| Zdroj: | Materials Advances Materials Advances, 2022, 3 (15), pp.6125-6141. ⟨10.1039/d2ma00410k⟩ |
| ISSN: | 2633-5409 |
| DOI: | 10.1039/d2ma00410k⟩ |
| Popis: | International audience; Injectable bone substitutes (IBS) represent compelling options for bone regenerative medicine as they can be used to optimally fill a complex bone defect through minimally invasive intervention. Since their discovery, calcium phosphate (CaP) based IBS have never stopped evolving to match the diverse clinical needs. The main challenge is to combine the desired physico-chemical and handling properties of the IBS to an optimal induced biological response. This cannot unfortunately be achieved with CaP biomaterials alone, hence a growing use of polymers and organic macromolecules as additives. To properly understand the ins and outs, a didactic classification of IBS is proposed in this review, which compiles the past, present and future developments of IBS. Class I IBS, taking advantage of ceramic particles or granules as the support for bone formation, are already commercialized and widely employed in clinics. In contrast, Class II IBS, where cements serve as a stiff matrix for the development of mineralized tissues, associated with polymers, are still in their early stages but have shown significant improvements versus Class I products. These innovative Class II IBS will be the second focal point of this review. |
| Databáze: | OpenAIRE |
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