Internal mammary nodes metastases for breast cancer: whether the morphological verification is necessary?
| Autor: | M V Chernikh, M I Nechushkin, V. A. Uimanov, A V Trigolosov, E. A Nikitina, A V Petrovskiy |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2017 |
| Předmět: |
Cancer Research
medicine.medical_specialty Axillary lymph nodes business.industry Lymphovascular invasion medicine.medical_treatment medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens lcsh:RC254-282 Metastasis Radiation therapy internal mammary nodes Breast cancer medicine.anatomical_structure breast cancer Oncology videothoracoscopic parasternal lymphadenectomy Parasternal line Medicine Lymphadenectomy Radiology business Lymph node |
| Zdroj: | Современная онкология, Vol 19, Iss 2, Pp 22-27 (2017) |
| ISSN: | 1815-1442 1815-1434 |
| Popis: | Background. Metastatic involvement of the internal mammary chain lymph nodes (IMN) is associated with poor prognosis for breast cancer (BC) patients. However, parasternal radiation therapy is still a subject for debate. Methods. Results of 1144 consecutively treated patients with primary BC, who underwent one-stage videothoracoscopic (VATS) parasternal lymphadenectomy from 1998 to 2009, were retrospectively studied. Results. Surgical complications associated with thoracoscopic procedure did not exceed 2%. IMN metastases were detected in 211 (18.4%) patients, 6.0% of these cases did not have axillary invasion. In a wide analysis, the frequency of metastasis was statistically more influenced by: tumor localization (different from external quadrants), primary tumor size (T), level of involved axillary lymph nodes (N) and lymphovascular invasion. Patients with IMN metastases showed significantly poorer long-term outcomes: 5-year overall - OS and disease-free survival - DFS (OS 79.0±3.1% vs 91.4±1.0%, p |
| Databáze: | OpenAIRE |
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