Neural responses to a modified Stroop paradigm in patients with complex chronic musculoskeletal pain compared to matched controls: an experimental functional magnetic resonance imaging study
| Autor: | Antony Robert Wilkes, Owen Hughes, Richard G. Wise, Judith Elizabeth Hall, Ashley D. Harris, Rhiannon Phillips, Alice Varnava, Ann Margaret Taylor |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Brain activity and meditation Emotions Audiology 0302 clinical medicine Musculoskeletal Pain Attention General Psychology Aged 80 and over education.field_of_study medicine.diagnostic_test fMRI Chronic pain Brain General Medicine Middle Aged Magnetic Resonance Imaging medicine.anatomical_structure Female Stroop Psychology psychological phenomena and processes Research Article Clinical psychology Adult medicine.medical_specialty Population Neuroimaging behavioral disciplines and activities 03 medical and health sciences RZ Reaction Time medicine Humans education Anterior cingulate cortex Aged Complex chronic pain Secondary somatosensory cortex medicine.disease 030227 psychiatry Oxygen Case-Control Studies Musculoskeletal Chronic Disease Stroop Test Functional magnetic resonance imaging 030217 neurology & neurosurgery Stroop effect |
| Zdroj: | BMC Psychology |
| ISSN: | 2050-7283 |
| Popis: | Background: Chronic musculoskeletal pain (CMSKP) is attentionally demanding, complex and multi-factorial; neuroimaging research in the population seen in pain clinics is sparse. A better understanding of the neural activity underlying attentional processes to pain related information compared to healthy controls may help inform diagnosis and management in the future. \ud Methods: Blood oxygenation level dependent functional magnetic resonance imaging (BOLD fMRI) compared brain responses in patients with CMSKP (n=15) and healthy controls (n=14) while completing a modified Stroop task using pain-related, positive-emotional, and neutral control words. \ud Results: Response times in the Stroop task were no different for CMSKP patients compared with controls, but patients were less accurate in their responses to all word types. BOLD fMRI responses during presentation of pain-related words suggested increases in neural activation in patients compared to controls in regions previously reported as being involved in pain perception and emotion: the anterior cingulate cortex, insula and primary and secondary somatosensory cortex. No fMRI differences were seen between groups in response to positive or control words. \ud Conclusions: Using this modified Stroop tasks, specific differences were identified in brain activity between CMSKP patients and controls in response to pain-related information using fMRI. This provided evidence of differences in the way that pain-related information is processed in those with chronic complex musculoskeletal pain that were not detectable using the behavioural measures of speed and accuracy. The study may be helpful in gaining new insights into the impact of attention in those living with chronic pain |
| Databáze: | OpenAIRE |
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