Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non-invasive laboratory tests

Autor:	B. Tramier, B. Robert, L. Le Page, Eric Nguyen-Khac, Denis Chatelain, Jean-Louis Dupas, J.-P. Joly, M. Brevet, S. Lion, P. Grignon, C. Decrombecque
Rok vydání:	2008
Předmět:	Adult Liver Cirrhosis Male medicine.medical_specialty Asymptomatic Gastroenterology Severity of Illness Index Liver Function Tests Fibrosis Predictive Value of Tests Internal medicine Medicine Humans Pharmacology (medical) Prospective Studies Hepatology Receiver operating characteristic medicine.diagnostic_test business.industry FibroTest Middle Aged medicine.disease Elasticity Alcoholism ROC Curve Predictive value of tests Liver biopsy Female medicine.symptom business Hepatic fibrosis Transient elastography Biomarkers
Zdroj:	Alimentary pharmacologytherapeutics. 28(10)
ISSN:	1365-2036
Popis:	Summary Background Systematic screening for liver fibrosis in heavy-drinking patients is a challenge. Aims To assess Fibroscan for non-invasive diagnosis of asymptomatic liver fibrosis in alcohol abuse patients, to determine diagnostic liver stiffness cut-off values and to compare performance of Fibroscan with seven non-invasive laboratory tests. Methods One hundred and three alcoholic patients were studied. Liver fibrosis was staged by METAVIR system. Fibroscan, Fibrotest, Fibrometer, Hepascore, APRI, PGA, PGAA and hyaluronic acid tests were performed. Liver stiffness cut-offs were determined using receiver-operating characteristic (ROC) curves. Results Liver stiffness was correlated with fibrosis (r = 0.72, P
Databáze:	OpenAIRE
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