True bipolar or extended bipolar left ventricular pacing is associated with better survival in cardiac resynchronization therapy patients

Autor:	Scott Wehrenberg, Valentina Kutyifa, Paul W. Jones, Sina Jame, Paul J. Wang, Kenneth M. Stein, D Musat
Rok vydání:	2020
Předmět:	Male medicine.medical_specialty medicine.medical_treatment Cardiac resynchronization therapy 030204 cardiovascular system & hematology Lower risk Cardiac Resynchronization Therapy 03 medical and health sciences 0302 clinical medicine Internal medicine mental disorders medicine Humans Clinical significance In patient Cardiac Resynchronization Therapy Devices Prospective Studies 030212 general & internal medicine Aged Aged 80 and over Heart Failure business.industry Hazard ratio Lead polarity General Medicine Middle Aged Ventricular pacing Survival Rate Cohort Cardiology Female Cardiology and Cardiovascular Medicine business
Zdroj:	Pacing and Clinical Electrophysiology. 43:412-417
ISSN:	1540-8159 0147-8389
Popis:	BACKGROUND Limited studies are available on the clinical significance of left ventricular (LV) lead polarity in patients undergoing cardiac resynchronization therapy (CRT), with a recent study suggesting better outcomes with LV true bipolar pacing. OBJECTIVE We aimed to determine whether true bipolar LV pacing is associated with reduced mortality in a large, real-life CRT cohort, followed by remote monitoring. METHODS We analyzed de-identified device data from CRT patients followed by the Boston Scientific LATITUDE remote monitoring database system. Patients with LV bipolar leads paced between the LV ring and LV tip were identified as true bipolar and those with LV bipolar leads paced between LV tip or LV ring and right ventricular (RV) coil were identified as extended bipolar. Patients with unipolar leads were identified as unipolar. RESULTS Of the 59 046 patients included in the study, 2927 had unipolar pacing, 34 390 had extended bipolar pacing, and 21 729 had true bipolar pacing. LV true bipolar pacing was associated with a significant 30% lower risk of all-cause mortality as compared to unipolar pacing (hazards ratio [HR] = 0.70, 95% CI: 0.62-0.79, P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304a04fd782705a46117b0160743db16 https://doi.org/10.1111/pace.13889 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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