Single-dose amoxicillin therapy of uncomplicated pediatric urinary tract infections
| Autor: | Julie R. Ingelfinger, John T. Herrin, Ellis D. Avner, Robert H. Rubin, Nina Tolkoff-Rubin, Eugenia Marcus, David A. Link, Linda Russell-Getz |
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| Rok vydání: | 1983 |
| Předmět: |
Male
Risk medicine.medical_specialty Adolescent Antibody-Coated Bacteria Test Urinary Urinary system Disease Gastroenterology law.invention Random Allocation Randomized controlled trial law Internal medicine medicine Humans Child Escherichia coli Infections Clinical Trials as Topic business.industry Amoxicillin Antimicrobial Predictive value Surgery Clinical trial Child Preschool Acute Disease Urinary Tract Infections Pediatrics Perinatology and Child Health Ambulatory Female business medicine.drug |
| Zdroj: | The Journal of Pediatrics. 102:623-627 |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/s0022-3476(83)80207-8 |
| Popis: | Forty-nine ambulatory children between 2-1/2 and 12 years of age with acute, clinically uncomplicated urinary tract infections caused by susceptible organisms were randomized to receive a single dose of amoxicillin based on weight or a 10-day course of amoxicillin therapy (conventional therapy). Patients receiving single doses of amoxicillin had a cure rate of 63%, which compares unfavorably with the cure rate of 92% in patients given conventional therapy. A failure of single-dose therapy predicted underlying radiologic abnormalities with a sensitivity of 60% and a specificity of 58%, making it a poor screening test for detecting those patients at risk for renal parenchymal damage. The antibody-coated bacteria assay had no predictive value in separating upper and lower tract disease, although it may predict underlying radiologic abnormalities. The data indicate that the response to single-dose amoxicillin therapy fails to separate upper from lower tract disease reliably and has a limited role in predicting response to conventional antimicrobial therapy. |
| Databáze: | OpenAIRE |
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