Two cases of Graves’ disease with presentation of unilateral diffuse uptake of radioisotopes
| Autor: | Ikuo Matsui, N. Sasano, M. Fukui, Toru Ogawa, Yoshiyuki Fuwa, Hiroshi Sarui, Shigeki Sakata, Hiroshi Takuno, H. Yuasa, S. Goto |
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| Rok vydání: | 1993 |
| Předmět: |
endocrine system
Pathology medicine.medical_specialty Goiter endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Graves' disease Radioimmunoassay Thyroid Gland Thyroid Function Tests Scintigraphy Malignancy Thyroid function tests Iodine Radioisotopes Mice Endocrinology medicine Animals Humans Radionuclide Imaging Methimazole medicine.diagnostic_test business.industry Thyroid Thyroidectomy Technetium Middle Aged medicine.disease Graves Disease Thyroxine medicine.anatomical_structure Triiodothyronine Female Histopathology business |
| Zdroj: | Journal of Endocrinological Investigation. 16:903-907 |
| ISSN: | 1720-8386 0391-4097 |
| DOI: | 10.1007/bf03348954 |
| Popis: | We present two cases of Graves' disease whose initial thyroidal scintiscan with 99mTcO4- (Case 1) and 123I (Case 2) showed unilateral diffuse uptake of radioisotopes. Initial diagnosis was possibility of malignancy in Case 1 and Graves' disease or Plummer's disease in Case 2. Both cases underwent right hemithyroidectomy. Histopathology of the resected thyroid gland in both showed hyperplastic columnar epithelium and infiltrative lymphocytes which was compatible with Graves' disease. Twenty seven (Case 1) and eight months (Case 2) after operation, both presented with thyrotoxic symptoms associated with enlarged left lobe, increased serum free thyroid hormone concentrations, suppressed TSH concentration, increased thyroidal 123I uptake in the remaining left lobe, and positive thyrotropin receptor antibodies. Both cases were successfully treated with methimazole. It was concluded that initial radioisotope uptake as well as scintigram in rare subgroup of patients with Graves' disease could be similar with that of non-autoimmune autonomous goiter (Plummer's disease). |
| Databáze: | OpenAIRE |
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