Effects of various fragrant ingredients on desmopressin-induced fluid retention in mice
| Autor: | Yasuo Morimoto, Yujiro Shibata |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Zingerone
Male Aromatherapy medicine.medical_treatment Pharmaceutical Science Mice Inbred Strains Pharmacology Cinnamaldehyde chemistry.chemical_compound Mice Furosemide Edema Cyclohexenes medicine Animals Deamino Arginine Vasopressin Desmopressin Diuretics Dose-Response Relationship Drug Chemistry Terpenes Guaiacol Dose–response relationship Disease Models Animal Biochemistry medicine.symptom Diuretic Limonene medicine.drug Antidiuretic |
| Zdroj: | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 130(7) |
| ISSN: | 0031-6903 |
| Popis: | Although fragrances are often used in aromatherapy for the treatment of edema, few studies on their diuretic and/or antiedematous activities have been performed. In this study, the effects of four types of fragrant ingredients (d-limonene, piperitone, alpha-pinene, and cinnamaldehyde) were examined in a mouse model of fluid retention. The mice were loaded with water after treatment with desmopressin (an antidiuretic hormone). In addition, zingerone, a pungent component of ginger which is considered to be effective in the treatment of edema, was examined. Moreover, their effects were compared with those of furosemide, a representative diuretic. Among the five types of fragrant ingredients examined, all except for cinnamaldehyde increased the urine volume in the fluid retention mouse model when administered at a dose of 100 mg/kg. In particular, d-limonene and zingerone significantly increased the urine volume. Thus the effects of these two ingredients were further examined at lower doses of 10 and 30 mg/kg. d-Limonene significantly increased the urine volume in a dose-dependent manner. Zingerone resulted in a significant increase in the urine volume only at a dose of 30 mg/kg. In normal mice, d-limonene did not affect the urine volume at the same doses. In contrast, zingerone significantly increased the urine volume in normal mice at a dose of 30 mg/kg. Furosemide significantly increased the urine volume in both the fluid-retentive and normal mice. These results indicate that both d-limonene and zingerone exhibit diuretic actions; however, the former fragrance only exerted an action in the fluid-retentive state. This different action suggests that d-limonene might be promising for the treatment of edema. |
| Databáze: | OpenAIRE |
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