Local delivery of bisphosphonate from coated orthopedic implants increases implants mechanical stability in osteoporotic rats

Autor: Pascal Janvier, Olivier Gauthier, Ralph Müller, Dominique P. Pioletti, Jean-Michel Bouler, Bruno Bujoli, Pierre-Yves Zambelli, Samia Laïb, G. Harry van Lenthe, Jérôme Guicheux, Bastian Peter
Přispěvatelé: Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)
Jazyk: angličtina
Rok vydání: 2006
Předmět:
Biocompatible
medicine.medical_specialty
Materials science
Osteolysis
Surface Properties
medicine.medical_treatment
0206 medical engineering
Osteoporosis
Population
Biomedical Engineering
Dentistry
02 engineering and technology
Zoledronic Acid
Bone and Bones
Biomaterials
Coated Materials
Biocompatible
medicine
Animals
Humans
Biomechanics
Rats
Wistar
education
Fixation (histology)
education.field_of_study
Diphosphonates
business.industry
Coated Materials
Metals and Alloys
Imidazoles
Prostheses and Implants
Bisphosphonate
021001 nanoscience & nanotechnology
medicine.disease
020601 biomedical engineering
Bone and Bones/drug effects/physiopathology/surgery
Biomechanical Phenomena
Rats
Orthopedic surgery
Ceramics and Composites
Ovariectomized rat
Microscopy
Electron
Scanning
Female
Implant
0210 nano-technology
business
Zdroj: Journal of Biomedical Materials Research Part A
Journal of Biomedical Materials Research Part A, Wiley, 2006, 76A, pp.133-143
ISSN: 1549-3296
1552-4965
Popis: Patients with osteoporosis and joint disabilities represent a constant growing and challenging population to be treated in the musculoskeletal clinical field. Especially in the case of total hip arthroplasty, new solutions should be developed to compensate for the double negative factors, peri-implant osteolysis, and osteoporotic bone loss, affecting the quality of implant outcome. The goal of this study was then to establish a proof of concept for orthopedic implant used as Zoledronate delivery in osteoporotic rats, and in particular, to verify if this approach could increase the initial implant stability. Twenty-five female 6-month-old Wistar rats were ovariectomized 6 weeks before the implantation to induce osteoporosis. The animals were randomly separated in five groups representing the different Zoledronate concentrations in the HA coating: 0, 0.2, 2.1, 8.5, and 16 microg/implant. Histomorphometric measures and peri-implant bone volume fraction were assessed and mechanical stability tests were performed. Bone volume fraction and biomechanical results clearly illustrate the positive effect of Zoledronate coated implants in the osteoporotic rats. A remarkable result was to show the existence of a window of Zoledronate content (0.2 to 8.5 microg/implant) in which the mechanical fixation of the implant increased. We were able to establish the proof of concept for orthopedic implants used as a drug delivery system in osteoporotic rats. The local bisphosphonate delivery from a calcium phosphate coating allowed increase of the mechanical fixation of an orthopedic implant. This study shows that orthopedic implants containing bisphosphonates could be beneficial for osteoporotic patients in need of a total joint replacement.
Databáze: OpenAIRE
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