Methylene Blue for Treatment of Hospitalized COVID-19 Patients: A Randomized, Controlled, Open-Label Clinical Trial, Phase 2
| Autor: | Daryoush Hamidi-Alamdari, Amin Ghiabi, Mahnaz Amini, George Koliakos, Seyed M. Tavousi, Abass Ali-Zeraati, Ahmad Bagheri-Moghaddam, Mahnaz Mozdourian, Ashraf Tavanaee-Sani, Hossin Safari, Shohreh Vojouhi, Fatemeh Barazandeh-Ahmadabadi, Marzieh Agheli-Rad, Saied Hafizi-Lotfabadi, Shahram Amini, Arash Peivandi-Yazdi, Farid Poursadegh, Alireza Sedaghat, Zahra Javidarabshahi, Negar Morovatdar, Shima Nabavi-Mahalli, Omid Rajabi, Seyed Majid-Hosseini |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Coronavirus disease 2019 (COVID-19) Respiratory distress Respiratory rate business.industry General Medicine Middle Aged Rate ratio COVID-19 Drug Treatment Hypoxemia Hospitalization Methylene Blue Clinical trial chemistry.chemical_compound chemistry Anesthesia medicine Humans Female medicine.symptom business Methylene blue Aged Oxygen saturation (medicine) |
| Zdroj: | Revista de investigaci�n Cl�nica. 73 |
| ISSN: | 0034-8376 |
| Popis: | Background: There is no pharmacological intervention on the treatment of hypoxemia and respiratory distress in COVID-19 patients. Objective: The objective of the study was to study the effect of the reduced form of methylene blue (MB) on the improvement of oxygen saturation (SpO2) and respiratory rate (RR). Methods: In an academic medical center, 80 hospitalized patients with severe COVID-19 were randomly assigned to receive either oral MB along with standard of care (SOC) (MB group, n = 40) or SOC only (SOC group, n=40). The primary outcomes were SpO2 and RR on the 3rd and 5th days. The secondary outcomes were hospital stay and mortality within 28 days. Results: In the MB group, a significant improvement in SpO2 and RR was observed on the 3rd day (for both, p < 0.0001) and also the 5th day (for both, p < 0.0001). In the SOC group, there was no significant improvement in SpO2 (p = 0.24) and RR (p = 0.20) on the 3rd day, although there was a significant improvement of SpO2 (p = 0.002) and RR (p = 0.01) on the 5th day. In the MB group in comparison to the SOC group, the rate ratio of increased SpO2 was 13.5 and 2.1 times on the 3rd and 5th days, respectively. In the MB group compared with the SOC group, the rate ratio of RR improvement was 10.1 and 3.7 times on the 3rd and 5th days, respectively. The hospital stay was significantly shortened in the MB group (p = 0.004), and the mortality was 12.5% and 22.5% in the MB and SOC groups, respectively. Conclusions: The addition of MB to the treatment protocols significantly improved SpO2 and respiratory distress in COVID-19 patients, which resulted in decreased hospital stay and mortality. ClinicalTrials.gov: NCT04370288. |
| Databáze: | OpenAIRE |
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