Biology of human melanocyte development, Piebaldism, and Waardenburg syndrome
| Autor: | Mohammed D. Saleem |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Waardenburg syndrome
Piebaldism Dermatology Computational biology Biology Melanocyte medicine.disease Phenotype Diagnosis Differential 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Mutation medicine Humans Melanocytes Waardenburg Syndrome |
| Zdroj: | Pediatric dermatology. 36(1) |
| ISSN: | 1525-1470 |
| Popis: | Melanocyte development is orchestrated by a complex interconnecting regulatory network of genes and synergistic interactions. Piebaldism and Waardenburg syndrome are neurocristopathies that arise from mutations in genes involved in this complex network. Our understanding of melanocyte development, Piebaldism, and Waardenburg syndrome has improved dramatically over the past decade. The diagnosis and classification of Waardenburg syndrome, first proposed in 1992 and based on phenotype, have expanded over the past three decades to include genotype. This review focuses on the current understanding of human melanocyte development and the evaluation and management of Piebaldism and Waardenburg syndrome. Management is often challenging and requires a multidisciplinary approach. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text