Aging and sarcopenia associate with specific interactions between gut microbes, serum biomarkers and host physiology in rats
| Autor: | Sonia Karaz, Mojgan Masoodi, Jay Siddharth, Delphine Morin-Rivron, Anirikh Chakrabarti, Jerome N. Feige, Scott J. Parkinson, Alice Pannerec |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Aging Sarcopenia Physiology microbiome Biology Sutterella Proteomics 03 medical and health sciences 0302 clinical medicine proteomics Microbial ecology Lipidomics medicine Animals Microbiome Bacteria Host (biology) muscle physiology Cell Biology Genomics medicine.disease biology.organism_classification Phenotype Gastrointestinal Microbiome Rats 030104 developmental biology Host-Pathogen Interactions lipidomics 030217 neurology & neurosurgery Biomarkers Genome Bacterial Research Paper |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| Popis: | The microbiome has been demonstrated to play an integral role in the maintenance of many aspects of health that are also associated with aging. In order to identify areas of potential exploration and intervention, we simultaneously characterized age-related alterations in gut microbiome, muscle physiology and serum proteomic and lipidomic profiles in aged rats to define an integrated signature of the aging phenotype. We demonstrate that aging skews the composition of the gut microbiome, in particular by altering the Sutterella to Barneseilla ratio, and alters the metabolic potential of intestinal bacteria. Age-related changes of the gut microbiome were associated with the physiological decline of musculoskeletal function, and with molecular markers of nutrient processing/availability, and inflammatory/immune status in aged versus adult rats. Altogether, our study highlights that aging leads to a complex interplay between the microbiome and host physiology, and provides candidate microbial species to target physical and metabolic decline during aging by modulating gut microbial ecology. |
| Databáze: | OpenAIRE |
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