Impact of two rounds of praziquantel mass drug administration on Schistosoma mansoni infection prevalence and intensity: a comparison between community wide treatment and school based treatment in western Kenya
| Autor: | Isaac O. Onkanga, Pauline N. M. Mwinzi, Ryan E. Wiegand, Geoffrey Muchiri, Martin Omedo, Susan P. Montgomery, W. Evan Secor, Diana M. S. Karanja, Kennedy Andiego |
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| Jazyk: | angličtina |
| Předmět: |
Adult
medicine.medical_specialty Adolescent 030231 tropical medicine Schistosomiasis Biology Article Praziquantel Feces Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine parasitic diseases medicine Prevalence Humans 030212 general & internal medicine Young adult Child Mass drug administration Parasite Egg Count School based treatment Community wide treatment ComputingMethodologies_COMPUTERGRAPHICS School Health Services Anthelmintics Infection prevalence Schistosoma mansoni Middle Aged medicine.disease biology.organism_classification Kenya Schistosomiasis mansoni Infectious Diseases Child Preschool Immunology Parasitology School based Delivery of Health Care medicine.drug |
| Zdroj: | International Journal for Parasitology |
| ISSN: | 0020-7519 |
| DOI: | 10.1016/j.ijpara.2016.01.006 |
| Popis: | Graphical abstract Highlights • Comparison of mass drug administration approaches for schistosomiasis was performed. • The study presents results of a mid-term analysis of a 5 year study. • School-based and community-wide distribution yielded a similar prevalence decrease. • School-based distribution had a greater impact on intensity of infection. This study compared the effectiveness of the community-wide treatment and school-based treatment approaches in the control of Schistosoma mansoni infections in villages with ⩾25% prevalence in western Kenya. Stool samples from first year students, 9–12 year olds and adults (20–55 years) were analyzed by the Kato–Katz technique for S. mansoni eggs. After two rounds of treatment, S. mansoni prevalence and intensity levels significantly declined in both treatment approaches. Prevalence comparisons between the two approaches did not show any significant differences following treatment. However, infection intensity levels in the 9–12 year old school-attending pupils were significantly higher in the community-wide treatment arm than in the school-based treatment arm. Nevertheless, significant reductions in S. mansoni infection prevalence and intensity levels were achieved among school-age children regardless of the treatment approach used. |
| Databáze: | OpenAIRE |
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