Basal growth hormone levels in women are positively correlated with high-density lipoprotein cholesterol and apolipoprotein A-I independently of insulin-like growth factor 1 or insulin
| Autor: | Dietmar Bänsch, Helmut Schulte, Changting Chen-Haudenschild, Astrid Dirkes-Kersting, Arnold von Eckardstein, Gerd Assmann |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
medicine.medical_specialty Apolipoprotein B Endocrinology Diabetes and Metabolism medicine.medical_treatment Insulin-like growth factor chemistry.chemical_compound Endocrinology High-density lipoprotein Internal medicine medicine Humans Insulin Insulin-Like Growth Factor I Triglycerides Pancreatic hormone Glycoproteins Lipoprotein lipase Apolipoprotein A-I C-Peptide biology Human Growth Hormone Cholesterol Cholesterol HDL Cholesterol Ester Transfer Proteins Lipoprotein Lipase Cross-Sectional Studies chemistry biology.protein Female lipids (amino acids peptides and proteins) Carrier Proteins Apolipoprotein A-II Lipoprotein |
| Zdroj: | Metabolism. 47:339-344 |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/s0026-0495(98)90268-2 |
| Popis: | Previous studies in growth hormone (GH)-deficient or acromegalic patients yielded contradictory results on the effect of GH on lipoprotein metabolism. In a cross-sectional study, we analyzed the relationships between unstimulated GH, insulin-like growth factor 1 (IGF1), insulin, and lipoprotein metabolism in 44 non-obese young women. On univariate analysis, basal serum levels of GH correlated positively with triglycerides, high-density lipoprotein (HDL) cholesterol, apolipoprotein A-I (apoA-I) and apoA-II and negatively with lipoprotein lipase (LPL) activity. These associations remained significant on multivariate analyses that, in addition to GH, took into account the effects of insulin or C-peptide, as well as the effects of total, protein-bound, or free IGF1. In most cases, the relationships of these lipid parameters with insulin/C-peptide and IGF1 and its free or protein-bound subfractions were opposite of those with GH and not significant. Thus, GH appears to regulate the metabolism of HDL and triglycerides independently of IGF1 and insulin. |
| Databáze: | OpenAIRE |
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