Development and characterization of cellulose-polymethacrylate mucoadhesive film for buccal delivery of carvedilol
| Autor: | Ansuman Patnaik, Kuldeep Singh Yadav, Narayan Prasad Yadav, Jaya Gopal Meher, Magdaline Tarai, Paresh Mishra |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Polymers and Plastics
Carbazoles Pharmacology In Vitro Techniques Methylcellulose Propanolamines chemistry.chemical_compound Drug Delivery Systems Hypromellose Derivatives Polymethacrylic Acids Materials Chemistry medicine Animals Cellulose chemistry.chemical_classification Goats Organic Chemistry Mouth Mucosa Adhesiveness Administration Buccal Polymer Buccal administration Permeation Solvent chemistry Methyl cellulose Carvedilol Swelling medicine.symptom Nuclear chemistry |
| Zdroj: | Carbohydrate polymers. 96(1) |
| ISSN: | 1879-1344 |
| Popis: | The aim of the present work was to develop and characterize mucoadhesive film of cellulose (methyl cellulose and hydroxy propyl methyl cellulose) and polymethacrylate (Eudragit RSPO) polymers for buccal delivery of carvedilol. Drug and polymers were found to be compatible as revealed by FTIR and DSC analysis. Mucoadhesive films were prepared by solvent casting technique. Swelling studies up to 4h did not show erosion of film, which was further confirmed by SEM analysis. New, simple and precise instrumental methods were established for the evaluation of mucoadhesive strength (33.8 ± 0.37-38.4 ± 0.24 g) and film strength (331.2 ± 0.73-369.0 ± 1.00 g) of developed films. Mucoadhesive film F5 showed 88 ± 1.15% in vitro drug release and 80 ± 2.30% ex vivo drug permeation through goat buccal mucosa in 12h. Drug release and permeation followed Higuchi's model and mechanism was found to be Fickian type diffusion controlled. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect