Differential inhibitory/stimulatory modulation of spinal CCK release by μ and δ opioid agonists, and selective blockade of μ-dependent inhibition by κ receptor stimulation
| Autor: | François Cesselin, Jean-Jacques Benoliel, Sylvie Bourgoin, Annie Mauborgne, J.C. Legrand, Michel Hamon |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Agonist medicine.medical_specialty Pyrrolidines medicine.drug_class Narcotic Antagonists Receptors Opioid mu Stimulation U-50488 In Vitro Techniques Opioid receptor Receptors Opioid delta Internal medicine medicine Animals Opioid peptide Cholecystokinin Analgesics Chemistry Receptors Opioid kappa General Neuroscience 3 4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide (trans)-Isomer Rats Inbred Strains Enkephalins Enkephalin Ala(2)-MePhe(4)-Gly(5) Rats Endocrinology Spinal Cord Opioid Receptors Opioid Morphine Oligopeptides Enkephalin Leucine medicine.drug |
| Zdroj: | Neuroscience Letters. 124:204-207 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(91)90094-a |
| Popis: | Opioid-cholecystokinin (CCK) interactions at the spinal level were investigated by looking for possible modulations by various opioid agonists of the release of cholecystokinin-like material (CCKLM) from slices of the dorsal zone of the rat lumbar enlargement. K(+)-evoked CCKLM overflow was reduced by 0.1-10 microM of the mu agonist DAGO or 10 nM to 3 microM of the delta agonist DTLET. By contrast, at a higer concentration (10 microM), the latter drug as well as morphine enhanced CCKLM overflow. Although inactive alone, the kappa opioid agonist U 50488 H (1 microM) prevented the inhibitory effect of DAGO without affecting that of DTLET. These data suggest that an opioid acting through the stimulation of mu, delta and kappa receptors (such as morphine) should produce a net increase in the spinal release of CCK. |
| Databáze: | OpenAIRE |
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